...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Environmental Research and Public Health >Genetic Analysis of West Nile Virus Isolates from an Outbreak in Idaho, United States, 2006–2007
【24h】

Genetic Analysis of West Nile Virus Isolates from an Outbreak in Idaho, United States, 2006–2007

机译：美国爱达荷州爆发的西尼罗河病毒分离株的遗传分析，2006–2007年

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

West Nile virus (WNV) appeared in the U.S. in 1999 and has since become endemic, with yearly summer epidemics causing tens of thousands of cases of serious disease over the past 14 years. Analysis of WNV strains isolated during the 2006–2007 epidemic seasons demonstrates that a new genetic variant had emerged coincidentally with an intense outbreak in Idaho during 2006. The isolates belonging to the new variant carry a 13 nt deletion, termed ID-Δ13, located at the variable region of the 3′UTR, and are genetically related. The analysis of deletions and insertions in the 3′UTR of two major lineages of WNV revealed the presence of conserved repeats and two indel motifs in the variable region of the 3′UTR. One human and two bird isolates from the Idaho 2006–2007 outbreaks were sequenced using Illumina technology and within-host variability was analyzed. Continued monitoring of new genetic variants is important for public health as WNV continues to evolve.
机译：西尼罗河病毒（WNV）于1999年在美国出现，此后成为地方病，过去14年中，每年的夏季流行病导致成千上万的严重疾病病例。对2006-2007年流行季节中分离出的WNV菌株进行的分析表明，在2006年期间，与爱达荷州的一次强烈暴发同时出现了一个新的遗传变异。属于该新变异的分离株带有13 nt缺失，称为ID-Δ13，位于3'UTR的可变区，并且具有遗传相关性。 WNV的两个主要谱系在3'UTR中的缺失和插入的分析表明，在3'UTR的可变区中存在保守的重复序列和两个indel模体。使用Illumina技术对爱达荷州2006 – 2007年暴发的1个人和2禽分离株进行了测序，并分析了宿主内部的变异性。随着WNV的不断发展，对新遗传变异的持续监测对于公共卫生至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号