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首页> 外文期刊>International Journal of Environmental Research and Public Health >Seminal Shedding of CMV and HIV Transmission among Men Who Have Sex with Men
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Seminal Shedding of CMV and HIV Transmission among Men Who Have Sex with Men

机译：与男性发生性关系的男性中巨细胞病毒和艾滋病毒传播的开创性发展

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As in many urban areas in the United States, the largest burden of the HIV epidemic in San Diego is borne by men who have sex with men (MSM). Using data from well-characterized HIV transmitting and non-transmitting partner pairs of MSM in San Diego, we calculated the population attributable risk (PAR) of HIV transmissions for different co-infections common among MSM in this area. We found that over a third of HIV transmissions could be potentially attributed to genital shedding of cytomegalovirus (CMV) (111 transmission events), compared to 21% potentially attributed to bacterial sexually transmitted infections (STI) (62 events) and 17% to herpes simplex virus type-2 (HSV-2) (51 events). Although our study cannot infer causality between the described associations and is limited in sample size, these results suggest that interventions aimed at reducing CMV shedding might be an attractive HIV prevention strategy in populations with high prevalence of CMV co-infection.
机译：与美国许多城市地区一样，圣地亚哥的艾滋病毒流行最大负担是与男男性接触者（MSM）。使用来自圣地亚哥的MSM的特征明确的HIV传播和非传播伙伴对的数据，我们计算了该地区MSM之间常见的不同合并感染的HIV传播的人群归因风险（PAR）。我们发现，超过三分之一的HIV传播可能归因于生殖器巨细胞病毒（CMV）脱落（111个传播事件），而21％可能归因于细菌性传播感染（STI）（62个事件）和17％归因于疱疹2型单纯形病毒（HSV-2）（51个事件）。尽管我们的研究无法推断出所描述的关联之间的因果关系，并且样本量有限，但这些结果表明，针对CMV合并感染率高的人群，旨在减少CMV脱落的干预措施可能是有吸引力的HIV预防策略。

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