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首页> 外文期刊>International Journal of Environmental Research and Public Health >Childhood Leukemia and 50 Hz Magnetic Fields: Findings from the Italian SETIL Case-Control Study
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Childhood Leukemia and 50 Hz Magnetic Fields: Findings from the Italian SETIL Case-Control Study

机译：儿童白血病和50 Hz磁场：意大利SETIL病例对照研究的发现

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We report on an Italian case-control study on childhood leukemia and exposure to extremely low frequency magnetic fields (ELF-MF). Eligible for inclusion were 745 leukemia cases, aged 0–10 years at diagnosis in 1998–2001, and 1475 sex- and age-matched population controls. Parents of 683 cases and 1044 controls (92% vs. 71%) were interviewed. ELF-MF measurements (24–48 h), in the child’s bedroom of the dwelling inhabited one year before diagnosis, were available for 412 cases and 587 controls included in the main conditional regression analyses. The magnetic field induction was 0.04 μT on average (geometric mean), with 0.6% of cases and 1.6% of controls exposed to 0.3 μT. The impact of changes in the statistical model, exposure metric, and data-set restriction criteria was explored via sensitivity analyses. No exposure-disease association was observed in analyses based on continuous exposure, while analyses based on categorical variables were characterized by incoherent exposure-outcome relationships. In conclusion, our results may be affected by several sources of bias and they are noninformative at exposure levels 0.3 μT. Nonetheless, the study may contribute to future meta- or pooled analyses. Furthermore, exposure levels among population controls are useful to estimate attributable risk.
机译：我们报道了一项有关儿童白血病和暴露于极低频磁场（ELF-MF）的意大利病例对照研究。符合条件的包括745例白血病病例，1998年至2001年诊断为0-10岁，以及1475个性别和年龄匹配的人群对照。采访了683例父母和1044例对照的父母（92％比71％）。诊断前一年，在住所儿童卧室内进行的ELF-MF测量（24-48小时）适用于主要条件回归分析中包括的412例病例和587例对照。磁场感应平均为0.04μT（几何平均值），其中0.6％的病例和1.6％的对照暴露于> 0.3μT。通过敏感性分析探索了统计模型，暴露指标和数据集限制标准中变化的影响。在基于连续暴露的分析中未观察到暴露与疾病的关联，而基于分类变量的分析则以不连贯的暴露-结果关系为特征。总而言之，我们的结果可能会受到几种偏见来源的影响，并且在暴露水平> 0.3μT时它们没有提供信息。尽管如此，该研究可能有助于将来的荟萃分析或合并分析。此外，人口控制中的接触水平对于估计可归因的风险很有用。

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