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首页> 外文期刊>International Journal of Environmental Research and Public Health >The Relationship between Scabies and Stroke: A Population-Based Nationwide Study
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The Relationship between Scabies and Stroke: A Population-Based Nationwide Study

机译：Sc疮与中风的关系：一项基于人口的全国研究

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Background: Scabies is a commonly occurring infectious skin infestation that substantially impacts the quality of life, while stroke, which consists of a neurological deficit resulting from a lack of blood flow to the brain, carries sizable economic costs. The pathophysiologic mechanisms underlying both diseases involve inflammatory processes that are mediated by the immune system; however, no prior research has been conducted to explore the relationship between the two conditions. Methods: This population-based nationwide study utilized data from the National Health Insurance Research Database (NHIRD) of Taiwan for a total of 6628 scabies patients, who comprised a scabies group, and a randomly selected cohort of 26,509 matching patients, who served as a control group. More specifically, the medical records for the patients in both groups were checked for seven years to identify any new cases of stroke within that seven-year follow-up period. The hazard ratio (HR) of stroke for the follow-up period was then calculated using Cox proportional hazards regressions, while comorbidities and demographic characteristics were likewise analyzed. Results: During the follow-up period, 2892 patients, or 8.7%, of the overall total of 33,137 patients included in the study were newly diagnosed with a stroke. Of those newly diagnosed stroke patients, 833 were from the scabies group, and 2059 were from the control group, accounting for 12.6% and 7.8%, respectively, of the individuals in each group. With a crude hazard ratio of 1.67, the patients in the scabies group had a significantly higher risk of subsequent stroke than those in the control group, although the adjusted hazard ratio (aHR) for the scabies patients, which was determined by adjusting for covariates, was only 1.32 (95% confidence interval (CI): 1.21–1.43). Conclusions: The results of the study indicated an elevated risk of stroke among scabies patients, an association that might be contributed to by immunopathological factors. This information could serve as a reminder to clinicians to remain alert to any indications of neurological impairment in patients previously infected with scabies.
机译：背景：Sc疮是一种常见的感染性皮肤病，会严重影响生活质量，而中风是由因缺乏血液流向大脑而导致的神经系统缺陷所构成的中坚经济损失。两种疾病的病理生理机制均涉及由免疫系统介导的炎症过程。但是，尚未进行任何先前的研究来探索这两种情况之间的关系。方法：这项基于人群的全国性研究利用台湾国家健康保险研究数据库（NHIRD）的数据，对总计6628例sc疮患者（包括a疮组）和随机选择的26509名匹配患者进行了队列研究。控制组。更具体地说，对两组患者的病历进行了7年的检查，以确定在该7年的随访期内是否有新的中风病例。然后使用Cox比例风险回归计算出随访期间中风的危险比（HR），同​​时对合并症和人口统计学特征进行分析。结果：在随访期间，纳入研究的33,137名患者中有2892名患者（占8.7％）是新诊断为中风的。在那些新诊断的中风患者中，疮组833例，对照组2059例，分别占每个组的12.6％和7.8％。尽管1.疮患者的调整后危险比（aHR）是通过调整协变量来确定的，但粗风险比为1.67时，the疮组的患者发生中风的风险比对照组高得多。仅为1.32（95％置信区间（CI）：1.21–1.43）。结论：研究结果表明sc疮患者中风的风险增加，这可能与免疫病理因素有关。该信息可以提醒临床医生对以前感染sc疮的患者的神经系统损害的任何迹象保持警觉。

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