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首页> 外文期刊>International Journal of Environmental Research and Public Health >Dose- and Time-Dependent Response of Human Leukemia (HL-60) Cells to Arsenic Trioxide Treatment
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Dose- and Time-Dependent Response of Human Leukemia (HL-60) Cells to Arsenic Trioxide Treatment

机译：人白血病（HL-60）细胞对三氧化二砷的剂量和时间依赖性反应

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The treatment of acute promyelocytic leukemia (APL) has been based on the administration of all-trans retinoic acid plus anthracycline chemotherapy, which is very effective as first line therapy; however 25 to 30% of patients will relapse with their disease becoming refractory to conventional therapy. Recently, studies have shown arsenic trioxide to be effective in the treatment of acute promyelocytic leukemia. In this study, we used the human leukemia (HL-60) cell line as a model to evaluate the cytoxicity of arsenic trioxide based on the MTT assay. Data obtained from this assay indicated that arsenic trioxide significantly reduced the viability of HL-60 cells, showing LD50 values of 14.26 + 0.5μg/mL, 12.54 + 0.3μg/mL, and 6.4 + 0.6μg/mL upon 6, 12, and 24 hours of exposure, respectively; indicating a dose- and time-dependent response relationship. Findings from the present study indicate that arsenic trioxide is highly cytotoxic to human leukemia (HL-60) cells, supporting its use as an effective therapeutic agent in the management of acute promyelocytic leukemia.
机译：急性早幼粒细胞白血病（APL）的治疗是基于全反式视黄酸加蒽环类化疗的综合治疗，作为一线治疗非常有效。然而，有25％到30％的患者会复发，其疾病对传统疗法难以治愈。最近，研究表明三氧化二砷可有效治疗急性早幼粒细胞白血病。在这项研究中，我们使用人类白血病（HL-60）细胞系作为模型，基于MTT分析评估三氧化二砷的细胞毒性。从该测定获得的数据表明，三氧化二砷显着降低了HL-60细胞的活力，在6、12和12岁时，LD50值分别为14.26 +0.5μg/ mL，12.54 +0.3μg/ mL和6.4 +0.6μg/ mL。分别暴露24小时;表明剂量和时间依赖的反应关系。从本研究中发现，三氧化二砷对人白血病（HL-60）细胞具有高度的细胞毒性，支持其用作急性早幼粒细胞白血病的有效治疗剂。

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