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Dietary Phthalate Exposure in Pregnant Women and the Impact of Consumer Practices

机译:孕妇饮食中邻苯二甲酸盐的摄入量和消费者行为的影响

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Phthalates are ubiquitous endocrine-disrupting chemicals that are contaminants in food and contribute to significant dietary exposures. We examined associations between reported consumption of specific foods and beverages and first trimester urinary phthalate metabolite concentrations in 656 pregnant women within a multicenter cohort study, The Infant Development and Environment Study (TIDES), using multivariate regression analysis. We also examined whether reported use of ecofriendly and chemical-free products was associated with lower phthalate biomarker levels in comparison to not following such practices. Consumption of one additional serving of dairy per week was associated with decreases of 1% in the sum of di-2-ethylhexyl phthalate (DEHP) metabolite levels (95% CI: ?2.0, ?0.2). Further, participants who reported sometimes eating homegrown food had monoisobutyl phthalate (MiBP) levels that were 16.6% lower (95% CI: ?29.5, ?1.3) in comparison to participants in the rarelyever category. In contrast to rarelyever eating frozen fruits and vegetables, participants who reported sometimes following this practice had monobenzyl phthalate (MBzP) levels that were 21% higher (95% CI: 3.3, 41.7) than rarely/ever respondents. Future study on prenatal dietary phthalate exposure and the role of consumer product choices in reducing such exposure is needed.
机译:邻苯二甲酸盐是破坏内分泌的无处不在的化学物质,是食物中的污染物,并导致大量的饮食接触。在多中心队列研究《婴儿发育与环境研究》(TIDES)中,我们使用多变量回归分析研究了656种孕妇报告的特定食品和饮料消费量与孕早期尿中邻苯二甲酸酯代谢物浓度之间的关系。我们还检查了与不遵循此类做法相比,报告的使用环保和不含化学药品的产品是否与较低的邻苯二甲酸酯生物标志物水平相关。每周多食用一份乳制品,与邻苯二甲酸二-2-乙基己酯(DEHP)代谢物总量的下降1%有关(95%CI:≤2.0,≤0.2)。此外,报告称有时会吃自制食品的参与者的邻苯二甲酸单异丁酯(MiBP)水平与“很少/从来没有”类别的参与者相比降低了16.6%(95%CI:?29.5,?1.3)。与很少/从未食用冷冻水果和蔬菜相比,参与者报告说,有时遵循这种做法,其邻苯二甲酸单苄酯(MBzP)水平比很少/从来没有受访者高21%(95%CI:3.3、41.7)。需要对产前饮食中邻苯二甲酸酯的暴露以及消费品选择在减少此类暴露中的作用进行进一步的研究。

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