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首页> 外文期刊>International Journal of Environmental Research and Public Health >Effects of Simulated Heat Waves on Cardiovascular Functions in Senile Mice
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Effects of Simulated Heat Waves on Cardiovascular Functions in Senile Mice

机译：模拟热波对老年小鼠心血管功能的影响

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摘要

The mechanism of the effects of simulated heat waves on cardiovascular disease in senile mice was investigated. Heat waves were simulated in a TEM1880 meteorological environment simulation chamber, according to a heat wave that occurred in July 2001 in Nanjing, China. Eighteen senile mice were divided into control, heat wave, and heat wave BH4 groups, respectively. Mice in the heat wave and heat wave BH4 groups were exposed to simulated heat waves in the simulation chamber. The levels of ET-1, NO, HSP60, SOD, TNF, sICAM-1, and HIF-1α in each group of mice were measured after heat wave simulation. Results show that heat waves decreased SOD activity in the myocardial tissue of senile mice, increased NO, HSP60, TNF, sICAM-1, and HIF-1α levels, and slightly decreased ET-1 levels, BH4 can relieve the effects of heat waves on various biological indicators. After a comprehensive analysis of the experiments above, we draw the followings conclusions regarding the influence of heat waves on senile mice: excess HSP60 activated immune cells, and induced endothelial cells and macrophages to secrete large amounts of ICAM-1, TNF-α, and other inflammatory cytokines, it also activated the inflammation response in the body and damaged the coronary endothelial cell structure, which increased the permeability of blood vessel intima and decreased SOD activity in cardiac tissues. The oxidation of lipoproteins in the blood increased, and large amounts of cholesterol were generated. Cholesterol penetrated the intima and deposited on the blood vessel wall, forming atherosclerosis and leading to the occurrence of cardiovascular disease in senile mice. These results maybe are useful for studying the effects of heat waves on elderly humans, which we discussed in the discussion chapter.
机译：研究了模拟热波对老年小鼠心血管疾病的作用机理。根据2001年7月在中国南京发生的热波，在TEM1880气象环境模拟室内模拟了热波。将十八只老年小鼠分别分为对照组，热浪和热浪BH4组。热波和热波BH4组中的小鼠在模拟室内暴露于模拟热波中。热波模拟后，测量每组小鼠的ET-1，NO，HSP60，SOD，TNF，sICAM-1和HIF-1α的水平。结果表明，热波降低了老年小鼠心肌组织中的SOD活性，NO，HSP60，TNF，sICAM-1和HIF-1α的水平升高，而ET-1的水平略有降低，BH4可以减轻热浪对心肌的影响。各种生物学指标。经过对上述实验的全面分析，我们得出了有关热波对衰老小鼠的影响的以下结论：过量的HSP60激活的免疫细胞，以及诱导的内皮细胞和巨噬细胞分泌大量ICAM-1，TNF-α和其他炎症细胞因子也激活体内的炎症反应并破坏冠状内皮细胞结构，从而增加了血管内膜的通透性并降低了心脏组织中的SOD活性。血液中脂蛋白的氧化增加，并生成大量胆固醇。胆固醇穿透内膜并沉积在血管壁上，形成动脉粥样硬化并导致老年小鼠发生心血管疾病。这些结果可能有助于研究热波对老年人的影响，我们将在讨论章节中进行讨论。

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