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首页> 外文期刊>International Journal of Environmental Research and Public Health >Parity, Age at First Birth, and Risk of Death from Asthma: Evidence from a Cohort in Taiwan
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Parity, Age at First Birth, and Risk of Death from Asthma: Evidence from a Cohort in Taiwan

机译:平价,初生年龄和哮喘死亡风险:来自台湾一个队列的证据

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This study was undertaken to examine whether there is an association between age at first birth and parity and risk of asthma death. The study cohort consisted of 1,292,462 women in Taiwan who had a first live birth between 1 January 1978 and 31 December 1987. We tracked each woman from the date of their first childbirth to 31 December 2009, and their vital status was ascertained by linking records with the computerized mortality database. Cox proportional hazard regression models were used to estimate hazard ratios of death from asthma associated with parity and age at first birth. A trend of increasing risk of asthma death was seen with increasing age at first birth. The adjusted hazard ratio was 0.75 (95% confidence interval (CI) = 0.53–1.08) among women with two live births and 0.53 (95% CI = 0.36–0.78) among those with three or more births, compared with women who had one live birth. There was a significant decreasing trend in adjusted hazard ratios of asthma death with increasing parity. This study is the first to provide evidences to support an association between reproductive factors (parity and early age at first birth) and the risk of asthma death.
机译:这项研究旨在检查初生年龄与胎龄和哮喘死亡风险之间是否存在关联。该研究队列由台湾的1,292,462名妇女组成,她们在1978年1月1日至1987年12月31日期间进行了首次活产。我们追踪了每名妇女从其第一次分娩之日至2009年12月31日的生命,并通过与记录之间的联系确定了她们的生命状态。死亡率计算机化数据库。使用Cox比例风险回归模型估算与第一胎的年龄和年龄相关的哮喘死亡的风险比。随着初生年龄的增加,哮喘死亡风险呈增加趋势。与分娩一胎的妇女相比,两胎活产的妇女的调整后风险比为0.75(95%置信区间(CI)= 0.53–1.08),三胎或三胎以上的妇女为0.53(95%CI = 0.36-0.78)。活产。随着平价的增加,调整的哮喘死亡风险比有明显下降的趋势。这项研究是第一个提供证据支持生殖因素(胎龄和初生年龄)与哮喘死亡风险之间关系的证据。

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