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首页> 外文期刊>International Journal of Environmental Research and Public Health >Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults
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Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults

机译：慢性吸烟和非吸烟成年人的区域脑灌注水平比较

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Chronic cigarette smoking is associated with numerous abnormalities in brain neurobiology, but few studies specifically investigated the chronic effects of smoking (compared to the acute effects of smoking, nicotine administration, or nicotine withdrawal) on cerebral perfusion (i.e., blood flow). Predominately middle-aged male (47 ± 11 years of age) smokers (n = 34) and non-smokers (n = 27) were compared on regional cortical perfusion measured by continuous arterial spin labeling magnetic resonance studies at 4 Tesla. Smokers showed significantly lower perfusion than non-smokers in the bilateral medial and lateral orbitofrontal cortices, bilateral inferior parietal lobules, bilateral superior temporal gyri, left posterior cingulate, right isthmus of cingulate, and right supramarginal gyrus. Greater lifetime duration of smoking (adjusted for age) was related to lower perfusion in multiple brain regions. The results indicated smokers showed significant perfusion deficits in anterior cortical regions implicated in the development, progression, and maintenance of all addictive disorders. Smokers concurrently demonstrated reduced blood flow in posterior brain regions that show morphological and metabolic aberrations as well as elevated beta amyloid deposition demonstrated by those with early stage Alzheimer disease. The findings provide additional novel evidence of the adverse effects of cigarette smoking on the human brain.
机译：慢性吸烟与大脑神经生物学的众多异常有关，但很少有研究专门研究吸烟对脑灌注（即血流）的慢性影响（与吸烟，尼古丁给药或尼古丁戒断的急性影响相比）。比较了中年男性（47±11岁）吸烟者（n = 34）和非吸烟者（n = 27）在连续4次特斯拉连续动脉自旋标记磁共振研究中测得的局部皮质灌注。吸烟者的双侧内侧和外侧眶额皮质，双侧下顶叶，双侧颞上回，左后扣带，右扣带和右上臀回的灌注显着低于非吸烟者。终生吸烟时间较长（根据年龄调整）与多个大脑区域的较低灌注有关。结果表明，吸烟者显示前皮质区域存在明显的灌注不足，这与所有成瘾性疾病的发生，发展和维持有关。吸烟者同时表现出大脑后部区域的血流减少，表现出早期阿尔茨海默氏病患者的形态和代谢异常，以及β淀粉样蛋白沉积升高。这些发现为吸烟对人脑的不利影响提供了新的证据。

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