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首页> 外文期刊>International Journal of Environmental Research and Public Health >Association between Eight Functional Polymorphisms and Haplotypes in the Cholesterol Ester Transfer Protein (CETP) Gene and Dyslipidemia in National Minority Adults in the Far West Region of China
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Association between Eight Functional Polymorphisms and Haplotypes in the Cholesterol Ester Transfer Protein (CETP) Gene and Dyslipidemia in National Minority Adults in the Far West Region of China

机译：胆固醇酯转移蛋白（CETP）基因的八个功能多态性和单元型与中国远西部少数民族成年人血脂异常的关系

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We have investigated the relationship between the polymorphisms and haplotypes in the CETP gene, and dyslipidemia among the Xinjiang Kazak and Uyghur populations in China. A total of 712 patients with dyslipidemia and 764 control subjects of CETP gene polymorphism at rs12149545, rs3764261, rs1800775, rs711752, rs708272, rs289714, rs5882, and rs1801706 loci were studied by the Snapshot method, linkage disequilibrium analysis and haplotype construction. The results are as follows: (1) the minor allele of eight loci of frequencies in the two groups were different from other results of similar studies in other countries; (2) In the linear regression analysis, the HDL-C levels of rs708272 TT, rs1800775 AA, rs289714 CC and rs711752 AA genotypes were significantly higher than those of other genotypes, however, the rs3764261 GG and rs12149545 GG genotypes were significantly lower than those of other genotypes in the two ethnic groups. The HDL-C levels of the rs12149545 GG genotype were lower than those of other genotypes; (3) in the control group, the rs708272 CT genotype of TG levels were lower than in the CC genotype, the T genotype of LDL-C levels were lower than in the CC genotype, and the HDL-C levels were higher than in the CT genotype; the rs1800775 AC genotype of TG levels were higher than in the AA genotype, the rs711752 AG genotype of TG levels were lower than in the GG genotype, the AA genotype LDL-C levels were lower than in the GG genotype, and the HDL-C levels were higher than in the AG genotype; the rs1800775 AC genotype of TG levels were higher than in the AA genotype. In the dyslipidemia group, the rs708272 TT genotype of TC and LDL-C levels were higher than in the CT genotype and the rs3764261 TT genotype of TC levels were higher than in the GG genotype. The rs711752 AA genotype of TC and LDL-C levels were higher than in the AG genotype, and the rs12149545 AA genotype of TC and LDL-C levels were higher than in the GG genotype; (4) perfect Linkage Disequilibrium was observed for two sets of two SNPs: rs3764261 and rs12149545; rs711752 and rs708272. (5) Using SHEsis software analysis, the five A/T/A/A/T/C/A/G, A/T/A/A/T/T/G/A, G/G/A/G/C/C/G/G, G/G/C/G/C/C/A/G and G/G/C/G/C/T/G/G haplotypes were between dyslipidemia group and control group statistically significantly different (p < 0.05 in each case). The polymorphism of CETP genes rs708272, rs3764261, rs1800775, rs711752, rs12149545 was closely related to the dyslipidemia in the Xinjiang Uyghur and Kazakh ethnic groups; and the rs708272 T, rs3764261 T, rs711752 A, and rs12149545 A alleles could reduce risk of dyslipidemia in the Uyghur and Kazakh populations, however, the rs1800775 C allele showed risk factors.
机译：我们调查了中国新疆哈萨克族和维吾尔族人群中CETP基因多态性和单倍型与血脂异常的关系。通过Snapshot方法，连锁不平衡分析和单倍型构建研究了712名血脂异常患者和764名对照CETP基因多态性在rs12149545，rs3764261，rs1800775，rs711752，rs708272，rs289714，rs5882和rs1801706位点的CETP基因多态性。结果如下：（1）两组八个频率位点的次要等位基因与其他国家类似研究的其他结果不同; （2）在线性回归分析中，rs708272 TT，rs1800775 AA，rs289714 CC和rs711752 AA基因型的HDL-C水平显着高于其他基因型，但是rs3764261 GG和rs12149545 GG基因型的HDL-C水平显着低于那些基因型两个民族中其他基因型的差异rs12149545 GG基因型的HDL-C水平低于其他基因型。 （3）对照组中rs708272 CT基因型的TG水平低于CC基因型，LDL-C水平的T基因型低于CC基因型，HDL-C水平高于CC基因型。 CT基因型; TG水平的rs1800775 AC基因型高于AA基因型，rs711752 AG基因型TG水平低于GG基因型，AA基因型LDL-C水平低于GG基因型，以及HDL-C高于AG基因型; TG水平的rs1800775 AC基因型高于AA基因型。在血脂异常组中，TC和LDL-C水平的rs708272 TT基因型高于CT基因型，而TC水平的rs3764261 TT基因型高于GG基因型。 TC和LDL-C水平的rs711752 AA基因型高于AG基因型，而TC和LDL-C水平的rs12149545 AA基因型高于GG基因型; （4）观察到两组两个SNP的完美连锁不平衡：rs3764261和rs12149545; rs711752和rs708272。 （5）使用SHEsis软件分析，五个A / T / A / A / T / C / A / G，A / T / A / A / T / T / G / A，G / G / A / G / C / C / G / G，G / G / C / G / C / C / A / G和G / G / C / G / C / T / G / G在血脂异常组和对照组之间的单倍型差异有统计学意义（每种情况下p <0.05）。 CETP基因rs708272，rs3764261，rs1800775，rs711752，rs12149545的多态性与新疆维吾尔族和哈萨克族的血脂异常密切相关。 rs708272 T，rs3764261 T，rs711752 A和rs12149545 A等位基因可降低维吾尔族和哈萨克族人群血脂异常的风险，但是rs1800775 C等位基因显示出危险因素。

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