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Potential pathway of anti-inflammatory effect by New Zealand honeys

机译：新西兰蜂蜜抗炎作用的潜在途径

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Abstract: The role of honey in wound healing continues to attract worldwide attention. This study examines the anti-inflammatory effect of four honeys on wound healing, to gauge its efficacy as a treatment option. Isolated phenolics and crude extracts from manuka (Leptospermum scoparium), kanuka (Kunzea ericoides), clover (Trifolium spp.), and a manuka/kanuka blend of honeys were examined. Anti-inflammatory assays were conducted in HEK-Blue?-2, HEK-Blue?-4, and nucleotide oligomerization domain (NOD)2-Wild Type (NOD2-WT) cell lines, to assess the extent to which honey treatment impacts on the inflammatory response and whether the effect was pathway-specific. Kanuka honey, and to a lesser extent manuka honey, produced a powerful anti-inflammatory effect related to their phenolic content. The effect was observed in HEK-Blue?-2 cells using the synthetic tripalmitoylated lipopeptide Pam3CysSerLys4 (Pam3CSK4) ligand, suggesting that honey acts specifically through the toll-like receptor (TLR)1/TLR2 signaling pathway. The manuka/kanuka blend and clover honeys had no significant anti-inflammatory effect in any cell line. The research found that kanuka and manuka honeys have an important role in modulating the inflammatory response associated with wound healing, through a pathway-specific effect. The phenolic content of honey correlates with its effectiveness, although the specific compounds involved remain to be determined.
机译：摘要：蜂蜜在伤口愈合中的作用继续引起全世界的关注。这项研究检查了四种蜂蜜对伤口愈合的抗炎作用，以评估其作为治疗选择的功效。检查了麦卢卡（Leptospermum scoparium），卡努卡（Kunzea ericoides），三叶草（Trifolium spp。）和麦卢卡/卡努卡蜂蜜的分离酚和粗提物。在HEK-Blue？-2，HEK-Blue？-4和核苷酸低聚结构域（NOD）2-野生型（NOD2-WT）细胞系中进行了抗炎试验，以评估蜂蜜处理对其影响的程度炎症反应以及其作用是否是通路特异性的。卡努卡蜂蜜和少量的麦卢卡蜂蜜产生了与酚含量有关的强效抗炎作用。使用合成的三棕榈酰化脂肽Pam3CysSerLys4（Pam3CSK4）配体在HEK-Blue？-2细胞中观察到了这种作用，表明蜂蜜通过通行费样受体（TLR）1 / TLR2信号通路特异性发挥作用。麦卢卡/卡努卡蜂蜜和三叶草蜂蜜在任何细胞系中均没有明显的抗炎作用。研究发现，卡努卡和麦卢卡蜂蜜通过途径特异性作用在调节与伤口愈合相关的炎症反应中起重要作用。蜂蜜中的酚含量与其有效性相关，尽管具体的化合物尚待确定。

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