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首页> 外文期刊>International Journal of General Medicine >Clinical profile, management, and outcome in patients with out of hospital cardiac arrest: insights from a 20-year registry
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Clinical profile, management, and outcome in patients with out of hospital cardiac arrest: insights from a 20-year registry

机译：院外心脏骤停患者的临床概况，管理和结果：来自20年注册表的见解

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Background: There is limited information regarding the clinical characteristics and outcome of out of hospital cardiac arrest (OHCA) in Middle Eastern patients. The aim of this study was to evaluate clinical characteristics, treatment, and outcomes in patients admitted following OHCA at a single center in the Middle East over a 20-year period.Methods: The data used for this hospital-based study were collected for patients hospitalized with OHCA in Doha, Qatar, between 1991 and 2010. Baseline clinical characteristics, in-hospital treatment, and outcomes were studied in comparison with the rest of the admissions.Results: A total of 41,453 consecutive patients were admitted during the study period, of whom 987 (2.4%) had a diagnosis of OHCA. Their average age was 57±15 years, and 72.7% were males, 56.5% were Arabs, and 30.9% were South Asians. When compared with the rest of the admissions taken as a reference, patients with OHCA were more likely to have diabetes mellitus (42.8% versus 39.1%, respectively, P=0.02), prior myocardial infarction (21.8% versus 19.2%, P=0.04), and chronic renal failure (7.4% versus 3.9%, P=0.001), but were less likely to have dyslipidemia (16.9% versus 25.4%, P=0.001). Further, 52.6% of patients had preceding symptoms, the most common of which was chest pain (27.2%) followed by dyspnea (24.8%). An initially shockable rhythm (ventricular fibrillation or ventricular tachycardia) was present in 25.1% of OHCA patients, with ST segment elevation myocardial infarction documented in 30.0%. Severely reduced left ventricular systolic function (ejection fraction ≤35%) was present in 53.2% of OHCA patients; 42.9% had cardiogenic shock requiring use of inotropes at presentation. An intra-aortic balloon pump was inserted in 3.6% of cases. Antiarrhythmic medications were used in 27.4% and thrombolytic therapy in 13.9%, and 10.8% underwent a percutaneous coronary procedure (coronary angiography ± percutaneous coronary intervention). The in-hospital mortality rate was 59.8%.Conclusion: OHCA was associated with higher incidences of diabetes, prior myocardial infarction, and chronic kidney disease as compared with the remaining admissions. Approximately half of the patients had no preceding symptoms. In-hospital mortality was high (59.8%), but similar to the internationally published data.
机译：背景：关于中东患者的临床特征和院外心脏骤停（OHCA）结局的信息有限。这项研究的目的是评估20年来在中东一个中心的OHCA术后入院的患者的临床特征，治疗和结果。方法：本项基于医院的研究收集的数据用于患者1991年至2010年在卡塔尔多哈的OHCA医院住院。与其余入院者进行了基线临床特征，医院内治疗和结局的比较研究。结果：在研究期间，共有41,453例连续患者入选，其中987名（2.4％）诊断为OHCA。他们的平均年龄为57±15岁，男性为72.7％，阿拉伯人为56.5％，南亚人为30.9％。与作为参考的其他入院者相比，OHCA患者更易患糖尿病（分别为42.8％和39.1％，P = 0.02），心肌梗死前（21.8％和19.2％，P = 0.04）。 ）和慢性肾衰竭（7.4％对3.9％，P = 0.001），但血脂异常的可能性较小（16.9％对25.4％，P = 0.001）。此外，有52.6％的患者有先前症状，其中最常见的是胸痛（27.2％），其次是呼吸困难（24.8％）。 OHCA患者中有25.1％最初出现令人震惊的心律（室颤或室性心动过速），而ST段抬高型心肌梗塞的发生率为30.0％。 OHCA患者中53.2％的患者左室收缩功能严重降低（射血分数≤35％）; 42.9％的人因心源性休克而需要使用正性肌力药。 3.6％的病例插入了主动脉内球囊泵。抗心律失常药物的使用率为27.4％，溶栓治疗的使用率为13.9％，并且10.8％的患者进行了经皮冠状动脉手术（冠状动脉造影±经皮冠状动脉介入治疗）。院内死亡率为59.8％。结论：与其余入院相比，OHCA与糖尿病，先前的心肌梗塞和慢性肾脏病的发病率更高有关。大约一半的患者没有先前的症状。院内死亡率很高（59.8％），但与国际公布的数据相似。

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