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首页> 外文期刊>International Journal of General Medicine >The relationship between vitamin D status and idiopathic lower-extremity deep vein thrombosis
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The relationship between vitamin D status and idiopathic lower-extremity deep vein thrombosis

机译：维生素D状态与特发性下肢深静脉血栓形成的关系

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Background: Vitamin D has been shown to have an anticoagulant effect. A decrease in 25-hydroxyvitamin D [25(OH)D] concentration has also been associated with an increased risk of venous thromboembolism. Hence, we sought to determine the relationship between 25(OH)D levels and idiopathic lower-extremity deep vein thrombosis (DVT). Methods: In a case control study, a total of 82 participants with idiopathic lower-extremity DVT were enrolled along with 85 sex- and age-matched healthy participants as controls. The plasma 25(OH)D levels were measured in all the studied samples. Results: The participants' mean age was 47.1±12.3 years. Baseline characteristics were not significantly different between the groups. The concentration of 25(OH)D was significantly lower in the DVT group compared to that of the control group (17.9±10.3 versus 23.1±12.5 ng/mL, P=0.004). The prevalence of participants with deficient 25(OH)D levels was significantly higher in the both DVT and control groups than those with sufficient 25(OH)D levels (68.3% versus 13.4%, and 49.4% versus 28.2%, respectively, P=0.027). In a multivariate analysis, 25(OH)D levels and sex were found to be the only independent predictors of DVT (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.02–1.08, P=0.001 and OR 0.51, 95% CI 0.26–1.00, P=0.049, respectively). Conclusion: Low levels of 25(OH)D are associated with idiopathic lower-extremity DVT. Further investigation is needed to establish determinants and probable causative role of 25(OH)D.
机译：背景：维生素D已被证明具有抗凝作用。 25-羟基维生素D [25（OH）D]浓度的降低也与静脉血栓栓塞的风险增加有关。因此，我们试图确定25（OH）D水平与特发性下肢深静脉血栓形成（DVT）之间的关系。方法：在一项病例对照研究中，共入选了82名特发性下肢DVT参与者，以及85名性别和年龄相匹配的健康参与者。在所有研究样品中测量血浆25（OH）D水平。结果：参与者的平均年龄为47.1±12.3岁。两组之间的基线特征无显着差异。 DVT组中25（OH）D的浓度明显低于对照组（17.9±10.3对23.1±12.5 ng / mL，P = 0.004）。 DVT组和对照组中25（OH）D含量不足的参与者的患病率均明显高于25（OH）D含量较高的参与者（分别为68.3％对13.4％和49.4％对28.2％，P = 0.027）。在多变量分析中，发现25（OH）D水平和性别是DVT的唯一独立预测因子（赔率[OR] 1.05、95％置信区间[CI] 1.02–1.08，P = 0.001和OR 0.51、95） ％CI 0.26–1.00，P = 0.049）。结论：低水平的25（OH）D与特发性下肢DVT相关。需要进一步调查以确定25（OH）D的决定因素和可能的致病作用。

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