• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of General Medicine >Antihypertensive combination therapy in primary care offices: results of a cross-sectional survey in Switzerland
【24h】

Antihypertensive combination therapy in primary care offices: results of a cross-sectional survey in Switzerland

机译：基层医疗机构的降压联合疗法：瑞士的一项横断面调查结果

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Most hypertensive patients need more than one substance to reach their target blood pressure (BP). Several clinical studies indicate the high efficacy of antihypertensive combinations, and recent guidelines recommend them in some situations even as initial therapies. In general practice they seem widespread, but only limited data are available on their effectiveness under the conditions of everyday life. The objectives of this survey among Swiss primary care physicians treating hypertensive patients were: to know the frequency of application of different treatment modalities (monotherapies, free individual combinations, single-pill combinations); to see whether there are relationships between prescribed treatment modalities and patient characteristics, especially age, treatment duration, and comorbidities; and to determine the response rate (percentage of patients reaching target BP) of different treatment modalities under the conditions of daily practice. Methods: This cross-sectional, observational survey among 228 randomly chosen Swiss primary care physicians analyzed data for 3,888 consecutive hypertensive patients collected at one single consultation. Results: In this survey, 31.9% of patients received monotherapy, 41.2% two substances, 20.9% three substances, and 4.7% more than three substances. By combination mode, 34.9% took free individual combinations and 30.0% took fixed-dose single-pill combinations. Combinations were more frequently given to older patients with a long history of hypertension and/or comorbidities. In total, 67.8% of patients achieved their BP target according to their physician's judgment. When compared, single-pill combinations were associated with a higher percentage of patients achieving target BP than free individual combinations and monotherapies for the total sample and for patients with comorbidity. Conclusion: Antihypertensive combination therapy was widely used in Swiss primary care practices. The number of prescribed substances depended on age, treatment duration, and type and number of comorbidities. Although the response rate was generally modest under the conditions of daily practice, it was higher for single-pill combinations than for monotherapies and free individual combinations. Further studies are needed to confirm these observations.
机译：背景：大多数高血压患者需要一种以上的物质才能达到目标血压（BP）。多项临床研究表明，降压药组合具有很高的疗效，最近的指南甚至在某些情况下建议将其作为初始疗法。在一般情况下，它们看起来很普遍，但是在日常生活条件下，关于其有效性的数据很少。这项针对高血压患者的瑞士基层医疗医生的调查目的是：了解不同治疗方式（单刀疗法，自由个体组合，单药组合）的应用频率;查看规定的治疗方式和患者特征之间是否存在关系，特别是年龄，治疗持续时间和合并症;并确定在日常操作条件下不同治疗方式的反应率（达到目标血压的患者百分比）。方法：这项对228名随机选择的瑞士初级保健医生进行的横断面，观察性调查分析了一次咨询中收集的3888名连续性高血压患者的数据。结果：在本次调查中，接受单一疗法的患者为31.9％，接受两种药物治疗的患者为41.2％，接受三种药物治疗的率为20.9％，并且接受三种疗法治疗的患者多为4.7％。通过组合方式，34.9％采取了自由的个人组合，30.0％采取了固定剂量的单药组合。高血压和/或合并症的病史较长的老年患者更常使用组合药物。根据医生的判断，总共有67.8％的患者达到了血压目标。比较时，单药组合与总样本量和合并症患者的免费个体组合和单一疗法相比，达到目标血压的患者比例更高。结论：降压联合疗法被广泛应用于瑞士的初级保健实践中。处方药的数量取决于年龄，治疗时间以及合并症的类型和数量。尽管在日常使用条件下反应率通常不高，但单药联合治疗的缓解率要高于单一疗法和游离个体联合治疗的缓解率。需要进一步的研究来确认这些观察结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号