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Prevention and treatment of venous thromboembolism during HRT: current perspectives

机译:HRT期间静脉血栓栓塞的预防和治疗:当前观点

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Abstract: Many large trials in the past 15 years have proven an increased risk of vascular complications in women using oral, mostly non-bioidentical, hormone therapy. The risk of vascular complications depends on the route of administration (oral versus transdermal), age, duration of administration, and type of hormones (bioidentical versus non-bioidentical). Acquired and/or hereditary thrombophilias (eg, factor V Leiden, prothrombin mutation G20210A, and others) lead to a further increase of risk for venous thromboembolism, stroke, or myocardial infarction. Therefore, bioidentical hormone therapy via the transdermal route seems to be the safest opportunity for hormone replacement therapy, although large trials for bioidentical hormone therapy are needed.
机译:摘要:过去15年中的许多大型试验证明,口服(主要是非生物同一性)激素疗法的女性患血管并发症的风险增加。血管并发症的风险取决于给药途径(口服或经皮),年龄,给药时间和激素类型(生物同一或非生物相同)。获得性和/或遗传性血栓形成(例如,因子V Leiden,凝血酶原突变G20210A等)导致静脉血栓栓塞,中风或心肌梗塞的风险进一步增加。因此,尽管需要进行大量的生物等效激素治疗试验,但通过透皮途径进行生物等效激素治疗似乎是最安全的激素替代疗法。

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