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首页> 外文期刊>International Journal of General Medicine >Omega-3 fatty acid supplementation and cognitive function: are smaller dosages more beneficial?
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Omega-3 fatty acid supplementation and cognitive function: are smaller dosages more beneficial?

机译：补充Omega-3脂肪酸和认知功能：较小的剂量更有益吗？

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Abstract: As longevity increases, so does the global prevalence of cognitive dysfunction. Numerous lifestyle and/or dietary interventions such as omega-3 fatty acids have been suggested to improve memory. Therefore, this study examined the consistency and strength of the impact of supplementation of omega-3 fatty acids on overall cognitive function using systematic reviews and meta-analytic methods. Of 905 studies retrieved from all searches, 12 randomized controlled trials were included in the meta-analysis. There were differences between studies reporting outcomes for single memory function parameters. Subgroup analysis of doses used (low versus high) indicated that subjects receiving low (<1.73 g/day) doses of omega-3 fatty acids had a significant reduction in cognitive decline rate (-0.07, 95% confidence interval -0.01, -0.02) but there was no evidence for beneficial effects at higher doses (+0.04, 95% confidence interval -0.06, +0.14) compared with the placebo group. This study suggests that omega-3 fatty acids may be beneficial in preventing memory decline at lower doses.
机译：【摘要】随着寿命的增加，认知功能障碍的全球患病率也在增加。已经提出了许多生活方式和/或饮食干预措施，例如omega-3脂肪酸，可以改善记忆力。因此，本研究使用系统评价和荟萃分析方法，研究了补充omega-3脂肪酸对整体认知功能影响的一致性和强度。在所有检索中检索的905项研究中，荟萃分析包括12项随机对照试验。报告单一记忆功能参数结果的研究之间存在差异。使用剂量（低剂量与高剂量）的亚组分析表明，接受低剂量（<1.73 g /天）的omega-3脂肪酸的受试者的认知下降率显着降低（-0.07，95％置信区间-0.01，-0.02 ），但没有证据表明与安慰剂组相比，更高剂量（+ 0.04，95％置信区间-0.06，+ 0.14）有有益作用。这项研究表明，omega-3脂肪酸可能有助于预防低剂量时记忆力下降。

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