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首页> 外文期刊>International Journal of Environmental Research and Public Health >Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation
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Effect of Naturally Occurring Ozone Air Pollution Episodes on Pulmonary Oxidative Stress and Inflammation

机译：自然发生的臭氧空气污染事件对肺氧化应激和炎症的影响

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This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chronic obstructive pulmonary disease (COPD) compared to controls. We measured biomarkers (nitriteitrate (NOx), 8-isoprostane) in exhaled breath condensate (EBC), spirometry, and respiratory symptoms in 11 former smokers with moderate-to-severe COPD and nine former smokers without airflow obstruction during periods of low and high ozone air pollution. High ozone levels were associated with increased NOx in EBC in both COPD (8.7 (±8.5) vs. 28.6 (±17.6) μmol/L on clean air vs. pollution days, respectively, p < 0.01) and control participants (7.6 (±16.5) vs. 28.5 (±15.6) μmol/L on clean air vs. pollution days, respectively, p = 0.02). There was no difference in pollution effect between COPD and control groups, and no difference in EBC 8-isoprostane, pulmonary function, or respiratory symptoms between clean air and pollution days in either group. Former smokers both with and without airflow obstruction developed airway oxidative stress and inflammation in association with ozone air pollution episodes.
机译：这项研究旨在确定夏季在美国犹他州盐湖谷自然发生的臭氧空气污染事件是否与慢性阻塞性肺疾病患者的肺部炎症和氧化应激增加，呼吸道症状增加以及肺功能下降有关疾病（COPD）与对照组比较。我们测量了11例中度至重度COPD前吸烟者和9例低气流期间无气流阻塞的前吸烟者的呼出气冷凝物（EBC），肺活量测定和呼吸道症状中的生物标志物（亚硝酸盐/硝酸盐（NOx），8-异前列腺素）和高臭氧空气污染。高臭氧水平与COPD（8.7（±8.5）和28.6（±17.6）μmol/ L的EBC中NOx的增加有关，在清洁空气与污染日分别为p <0.01）和对照参与者（7.6（±清洁空气与污染天数分别为16.5）和28.5（±15.6）μmol/ L，p = 0.02）。清洁空气和污染天数之间，COPD和对照组之间的污染效果无差异，EBC 8-异前列腺素，肺功能或呼吸道症状也无差异。不论有无气流阻塞的前吸烟者，都会产生气道氧化应激和炎症，并伴有臭氧空气污染事件。

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