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首页> 外文期刊>International Journal of Environmental Research and Public Health >Sex-Dependent Depression-Like Behavior Induced by Respiratory Administration of Aluminum Oxide Nanoparticles
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Sex-Dependent Depression-Like Behavior Induced by Respiratory Administration of Aluminum Oxide Nanoparticles

机译：呼吸给药氧化铝纳米颗粒诱导的性别依赖性抑郁样行为

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摘要

Ultrafine aluminum oxide, which are abundant in ambient and involved occupational environments, are associated with neurobehavioral alterations. However, few studies have focused on the effect of sex differences following exposure to environmental Al2O3 ultrafine particles. In the present study, male and female mice were exposed to Al2O3 nanoparticles (NPs) through a respiratory route. Only the female mice showed depression-like behavior. Although no obvious pathological changes were observed in mice brain tissues, the neurotransmitter and voltage-gated ion channel related gene expression, as well as the small molecule metabolites in the cerebral cortex, were differentially modulated between male and female mice. Both mental disorder-involved gene expression levels and metabolomics analysis results strongly suggested that glutamate pathways were implicated in sex differentiation induced by Al2O3 NPs. Results demonstrated the potential mechanism of environmental ultrafine particle-induced depression-like behavior and the importance of sex dimorphism in the toxic research of environmental chemicals.
机译：在周围环境和涉及的职业环境中丰富的超细氧化铝与神经行为改变有关。然而，很少有研究关注于暴露于环境Al 2 O 3 超细颗粒后性别差异的影响。在本研究中，雄性和雌性小鼠通过呼吸途径暴露于Al 2 O 3 纳米颗粒（NPs）。仅雌性小鼠表现出抑郁样行为。尽管在小鼠脑组织中未观察到明显的病理变化，但在雌性和雄性小鼠中，神经递质和电压门控离子通道相关基因的表达以及大脑皮层中的小分子代谢产物受到不同的调节。涉及精神障碍的基因表达水平和代谢组学分析结果均强烈提示，谷氨酸途径与Al 2 O 3 NP诱导的性别分化有关。结果证明了环境超细颗粒诱导的抑郁样行为的潜在机制以及性别二态性在环境化学物质毒性研究中的重要性。

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