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首页> 外文期刊>International Journal of Environmental Research and Public Health >High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis
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High Birth Weight Increases the Risk for Bone Tumor: A Systematic Review and Meta-Analysis

机译：高出生体重增加了骨肿瘤的风险：系统评价和荟萃分析

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There have been several epidemiologic studies on the relationship between high birth weight and the risk for bone tumor in the past decades. However, due to the rarity of bone tumors, the sample size of individual studies was generally too small for reliable conclusions. Therefore, we have performed a meta-analysis to pool all published data on electronic databases with the purpose to clarify the potential relationship. According to the inclusion and exclusion criteria, 18 independent studies with more than 2796 cases were included. As a result, high birth weight was found to increase the risk for bone tumor with an Odds Ratio (OR) of 1.13, with the 95% confidence interval (95% CI) ranging from 1.01 to 1.27. The OR of bone tumor for an increase of 500 gram of birth weight was 1.01 (95% CI 1.00–1.02; p = 0.048 for linear trend). Interestingly, individuals with high birth weight had a greater risk for osteosarcoma (OR = 1.22, 95% CI 1.06–1.40, p = 0.006) than those with normal birth weight. In addition, in the subgroup analysis by geographical region, elevated risk was detected among Europeans (OR = 1.14, 95% CI 1.00–1.29, p = 0.049). The present meta-analysis supported a positive association between high birth weight and bone tumor risk.
机译：在过去的几十年中，已经有几项关于高出生体重与骨肿瘤风险之间关系的流行病学研究。但是，由于骨肿瘤的稀有性，个别研究的样本量通常太小，无法得出可靠的结论。因此，我们进行了荟萃分析，以汇总电子数据库中所有已发布的数据，以阐明潜在的关系。根据纳入和排除标准，纳入18项独立研究，涉及2796例以上。结果，高出生体重被发现会增加患骨肿瘤的风险，赔率（OR）为1.13，95％的置信区间（95％CI）为1.01至1.27。出生体重增加500克时，骨肿瘤的OR为1.01（95％CI 1.00-1.02;线性趋势p = 0.048）。有趣的是，出生体重高的人比正常体重的人骨肉瘤的风险更高（OR = 1.22，95％CI 1.06-1.40，p = 0.006）。此外，在按地理区域进行的亚组分析中，发现欧洲人的风险升高（OR = 1.14，95％CI 1.00-1.29，p = 0.049）。本荟萃分析支持高出生体重与骨肿瘤风险之间的正相关。

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