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首页> 外文期刊>International Journal of Environmental Research and Public Health >Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data
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Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data

机译：多发性骨髓瘤和草甘膦的使用：美国农业健康研究（AHS）数据的重新分析

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A previous publication of 57,311 pesticide applicators enrolled in the US Agricultural Health Study (AHS) produced disparate findings in relation to multiple myeloma risks in the period 1993–2001 and ever-use of glyphosate (32 cases of multiple myeloma in the full dataset of 54,315 applicators without adjustment for other variables: rate ratio (RR) 1.1, 95% confidence interval (CI) 0.5 to 2.4; 22 cases of multiple myeloma in restricted dataset of 40,719 applicators with adjustment for other variables: RR 2.6, 95% CI 0.7 to 9.4). It seemed important to determine which result should be preferred. RRs for exposed and non-exposed subjects were calculated using Poisson regression; subjects with missing data were not excluded from the main analyses. Using the full dataset adjusted for age and gender the analysis produced a RR of 1.12 (95% CI 0.50 to 2.49) for ever-use of glyphosate. Additional adjustment for lifestyle factors and use of ten other pesticides had little effect (RR 1.24, 95% CI 0.52 to 2.94). There were no statistically significant trends for multiple myeloma risks in relation to reported cumulative days (or intensity weighted days) of glyphosate use. The doubling of risk reported previously arose from the use of an unrepresentative restricted dataset and analyses of the full dataset provides no convincing evidence in the AHS for a link between multiple myeloma risk and glyphosate use.
机译：先前参与美国农业健康研究（AHS）的57,311名农药施用者的出版物在1993-2001年期间与多发性骨髓瘤风险和曾经使用过草甘膦有关的发现不同（在54,315个完整数据集中有32例多发性骨髓瘤）没有对其他变量进行调整的应用者：比率（RR）1.1，95％置信区间（CI）0.5至2.4;在40,719个应用者的受限数据集中22例多发性骨髓瘤，对其他变量进行了调整：RR 2.6，95％CI 0.7至9.4）。确定哪个结果应该是首选似乎很重要。使用泊松回归计算暴露和未暴露受试者的RR。数据缺失的受试者未排除在主要分析之外。使用针对年龄和性别调整的完整数据集，该分析得出的草甘膦使用率相对比为1.12（95％CI为0.50至2.49）。生活方式因素和其他十种农药的使用的额外调整几乎没有效果（RR 1.24，95％CI 0.52至2.94）。与报道的草甘膦累积使用天数（或强度加权天数）相关的多发性骨髓瘤风险没有统计学上的显着趋势。先前报告的风险增加是由于使用了无代表性的受限数据集而引起的，而对整个数据集的分析并未在AHS中提供令人信服的证据表明多发性骨髓瘤风险与草甘膦的使用之间存在联系。

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