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首页> 外文期刊>International Journal of General Medicine >Neuropeptide Y level in paraventricular nucleus of experimental diabetic rats: correlation with sympathetic activity and body weight
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Neuropeptide Y level in paraventricular nucleus of experimental diabetic rats: correlation with sympathetic activity and body weight

机译：实验性糖尿病大鼠脑室旁核中神经肽Y水平：与交感神经活动和体重的关系

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Abstract: Neuropeptide Y (NPY), colocalized with norepinephrine neuron, is known to modulate sympathetic activity and feeding behavior. Although experimental type 1 diabetes has increased sympathetic activity at the early part of the disease process, little effort was made so far to understand the correlation between NPY level in the hypothalamus and sympathetic activity in diabetes. Male Sprague Dawley rats were made diabetic by a single injection of streptozotocin (65 mg/kg body weight, IV). The animals were then studied after 2, 4, and 8 weeks. Control animals received only citrate vehicle. In an effort to clarify the modulatory effect of NPY at the early stage of diabetes, the paraventricular nucleus (PVN) of hypothalamus was sampled by microdialysis for NPY and norepinephrine level. While NPY level was increased immediately within 2 weeks (along with feeding behavior), norepinephrine level was increased only after 8 weeks following injection of streptozotocin. The animals lost significant weight. These results are interpreted to mean that a strong correlation exists between the feeding behavior and NPY level in PVN. Since NPY is known to inhibit sympathetic activity it is possible that NPY receptors are down-regulated following diabetes. The higher level of norepinephrine indicating higher sympathetic activity did not allow the animals to gain weight. In addition, controversy exists regarding pleiotropic activities of NPY related to the feeding behavior of these animals.
机译：摘要：与去甲肾上腺素神经元共定位的神经肽Y（NPY）可以调节交感神经活动和进食行为。尽管实验性1型糖尿病在疾病过程的早期增加了交感神经活动，但迄今为止，人们几乎没有做出任何努力来了解下丘脑中NPY水平与糖尿病交感神经活动之间的相关性。通过单次注射链脲佐菌素（65 mg / kg体重，静脉注射）使雄性Sprague Dawley大鼠患上糖尿病。然后在2、4和8周后对动物进行研究。对照动物仅接受柠檬酸盐载体。为了阐明NPY在糖尿病早期的调节作用，通过微透析对下丘脑的室旁核（PVN）进行了NPY和去甲肾上腺素水平的采样。尽管NPY水平在2周内立即升高（以及进食行为），但去甲肾上腺素水平仅在注射链脲佐菌素后8周后升高。动物体重减轻。这些结果被解释为意味着PVN的进食行为和NPY水平之间存在很强的相关性。由于已知NPY会抑制交感神经活动，因此糖尿病后NPY受体可能会下调。较高的去甲肾上腺素水平表明较高的交感神经活动使动物不增重。另外，关于NPY的多效性活动与这些动物的进食行为有关还存在争议。

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