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首页> 外文期刊>International Journal of Diabetes Research >Lack of Association of the Ghrelin Gene Arg51Gln Single Nucleotide Polymorphism with Obesity and Metabolic Syndrome among Multi-ethnic Malaysian Subjects
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Lack of Association of the Ghrelin Gene Arg51Gln Single Nucleotide Polymorphism with Obesity and Metabolic Syndrome among Multi-ethnic Malaysian Subjects

机译：Ghrelin 基因Arg51Gln单核苷酸多态性与肥胖和代谢综合征的多种族马来西亚受试者之间缺乏关联。

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Obesity and metabolic syndrome has become a public health concern because of its association with a number of medical complications that lead to increased morbidity and mortality. Ghrelin is a hormone that is primarily secreted in the stomach, which plays an important role to increase hunger through its action on hypothalamic feeding. The Ghrelin gene Arg51Gln single nucleotide polymorphism (SNP) (rs34911341) has been associated with obesity and metabolic syndrome in previous studies. Therefore, this study was to examine the prevalence of this SNP and its association with obesity, obesity-related traits and metabolic syndrome among 184 multi-ethnic Malaysian subjects (67 males, 117 females; 76 obese, 108 non obese; 52 Malay, 91 ethnic Chinese, 41 ethnic Indians) from the Kampar Health Clinic cohort. Demographic data, anthropometric and clinical measurements of subjects were collected. Genotyping was performed by using the genomic DNA extracted from leukocytes, followed by Polymerase Chain Reaction and SacI Restriction Fragment Length Polymorphism, revealing 113 GG, 70 GA and 1 AA subjects; minor allele frequency 0.196. Arg51Gln alleles did not show any association with obesity (p = 0.643), gender (p = 0.064) and ethnicity (p = 0.390). Besides, it did not show any association with the presence of metabolic syndrome according to 3 criteria in the modified NCEP ATP III for Asians (p = 0.931). Anthropometric and clinical measurements indicative of obesity and metabolic syndrome were also all not significantly different between the alleles. In conclusion, the Ghrelin Arg51Gln gene variant was not associated with obesity, obesity-related traits and metabolic syndrome among Malaysian subjects in this study.
机译：肥胖和代谢综合症已引起公众关注，因为它与许多导致并发症和死亡率增加的医学并发症相关。 Ghrelin是一种主要在胃中分泌的激素，通过其对下丘脑喂养的作用，在增加饥饿感方面起着重要作用。在以前的研究中，Ghrelin基因Arg51Gln单核苷酸多态性（SNP）（rs34911341）与肥胖症和代谢综合征相关。因此，本研究旨在检查184个多族裔马来西亚受试者（男性67例，女性117例;肥胖76例，非肥胖108例; 52例）中该SNP的流行及其与肥胖，肥胖相关性状和代谢综合征的相关性。金宝保健诊所队列中的马来人（91个华裔，41个印度裔）。收集受试者的人口统计学数据，人体测量学和临床测量值。通过从白细胞中提取基因组DNA进行基因分型，然后进行聚合酶链反应和SacI限制性片段长度多态性分析，发现113 GG，70 GA和1 AA受试者。次要等位基因频率为0.196。 Arg51Gln等位基因与肥胖症（p = 0.643），性别（p = 0.064）和种族（p = 0.390）没有任何关联。此外，在亚洲人的改良NCEP ATP III中，根据3个标准​​，它与代谢综合征的存在没有任何关联（p ＝ 0.931）。肥胖和代谢综合征的人体测量和临床测量在等位基因之间也没有显着差异。总之，在该研究中，Ghrelin Arg51Gln基因变异与肥胖，肥胖相关性状和代谢综合征无关。

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