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首页> 外文期刊>International Journal of Health Geographics >Correlations between meteorological parameters and prostate cancer
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Correlations between meteorological parameters and prostate cancer

机译：气象参数与前列腺癌的相关性

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Background There exists a north-south pattern to the distribution of prostate cancer in the U.S., with the north having higher rates than the south. The current hypothesis for the spatial pattern of this disease is low vitamin D levels in individuals living at northerly latitudes; however, this explanation only partially explains the spatial distribution in the incidence of this cancer. Using a U.S. county-level ecological study design, we provide evidence that other meteorological parameters further explain the variation in prostate cancer across the U.S. Results In general, the colder the temperature and the drier the climate in a county, the higher the incidence of prostate cancer, even after controlling for shortwave radiation, age, race, snowfall, premature mortality from heart disease, unemployment rate, and pesticide use. Further, in counties with high average annual snowfall (>75 cm/yr) the amount of land used to grow crops (a proxy for pesticide use) was positively correlated with the incidence of prostate cancer. Conclusion The trends found in this USA study suggest prostate cancer may be partially correlated with meteorological factors. The patterns observed were consistent with what we would expect given the effects of climate on the deposition, absorption, and degradation of persistent organic pollutants including pesticides. Some of these pollutants are known endocrine disruptors and have been associated with prostate cancer.
机译：背景技术在美国，前列腺癌的分布呈南北向分布，北部的患病率高于南部。对于这种疾病的空间格局，目前的假设是生活在北纬地区的人体内维生素D水平低;但是，该解释仅部分解释了该癌症发生率的空间分布。使用美国县级生态研究设计，我们提供证据表明其他气象参数进一步解释了全美国前列腺癌​​的变化。结果总体上，一个县的温度越冷，气候越干燥，前列腺癌的发病率就越高。即使控制了短波辐射，年龄，种族，降雪，心脏病导致的过早死亡，失业率和杀虫剂使用，也能预防癌症。此外，在年平均降雪量较高（> 75厘米/年）的县中，用于种植农作物（用作农药使用的土地）的土地数量与前列腺癌的发病率呈正相关。结论在这项美国研究中发现的趋势表明，前列腺癌可能与气象因素部分相关。考虑到气候对包括农药在内的持久性有机污染物的沉积，吸收和降解的影响，所观察到的模式与我们的预期一致。这些污染物中的一些是已知的内分泌干扰物，并与前列腺癌有关。

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