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首页> 外文期刊>International Journal of Chronic Obstructive Pulmonary Disease >The association between daily exacerbation symptoms and physical activity in patients with chronic obstructive pulmonary disease
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The association between daily exacerbation symptoms and physical activity in patients with chronic obstructive pulmonary disease

机译：慢性阻塞性肺疾病患者每日加重症状与体力活动的关系

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Background: Evidence from longitudinal studies on the impact of exacerbation symptoms on physical activity in chronic obstructive pulmonary disease (COPD) is lacking. The aim of this first exploratory study was to assess the association between exacerbation symptoms and physical activity, and to quantify the relative influence of specific symptoms. Methods: We recruited COPD patients at high risk for exacerbations from 2 pulmonary rehabilitation clinics and 1 acute care clinic in Switzerland. For 3 months after discharge, patients completed a daily symptom diary on a smartphone application, the EXAcerbations of Chronic pulmonary disease Tool (EXACT), and wore a pedometer to measure daily steps. We used mixed-effects models to determine the association of daily steps with exacerbation symptoms. Results: A total of 21 patients (Global Initiative for Chronic Obstructive Lung Disease grades 2–4) were enrolled for a mean of 94.4 days (standard deviation 4.2). The baseline median number of daily steps was 3,264.6 (interquartile range [IQR]: 1,851.3–4,784.1) and EXACT score was 37.0 (IQR: 30.9–41.4). A 12-point increase in EXACT score (indicating the start of an exacerbation) was statistically significantly associated with a decrease in daily steps of 653.3 (95% CI 969.7–336.9). Chest symptoms (tightness, discomfort and congestion) were more strongly associated with change in steps than breathlessness, and cough and sputum (z-value -4.5 vs -2.9 and -3.0). Conclusion: This is the first study to show that, in a small cohort of COPD patients, increases in exacerbation symptoms were associated with a statistically and clinically significant reduction in daily physical activity. These results underscore the importance for symptom control and exacerbation prevention in COPD patients.
机译：背景：关于慢性阻塞性肺疾病（COPD）加重症状对体育锻炼影响的纵向研究缺乏证据。这项首次探索性研究的目的是评估急性发作症状与体育锻炼之间的关联，并量化特定症状的相对影响。方法：我们从瑞士的2家肺康复诊所和1家急诊诊所招募了有加重高危风险的COPD患者。出院后3个月，患者在智能手机应用程序《慢性肺疾病工具EXAcerbations》（EXACT）上完成了每日症状日记，并佩戴了计步器来测量每日步数。我们使用混合效应模型来确定日常步伐与急性发作症状的关联。结果：总共21例患者（全球慢性阻塞性肺疾病倡议2-4级）入组，平均94.4天（标准差4.2）。日步的基线中位数为3,264.6（四分位间距[IQR]：1,851.3–4,784.1），EXACT得分为37.0（IQR：30.9–41.4）。 EXACT得分增加12分（表明发作开始）与每天减少653.3（95％CI 969.7-336.9）的统计显着相关。胸部症状（紧张，不适和充血）与步态变化的相关性比呼吸困难，咳嗽和痰多（z值-4.5对-2.9和-3.0）。结论：这是第一项研究表明，在一小群COPD患者中，病情加重症状与每日体力活动的统计学和临床​​显着减少有关。这些结果强调了COPD患者控制症状和加重病情的重要性。

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