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首页> 外文期刊>International Journal of Hepatology >Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma
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Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma

机译：真核翻译起始因子5A（eIF5A）在肝细胞癌预后和治疗中的意义

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摘要

Hepatocellular carcinoma (HCC) is a primary liver malignancy and accounts for most of the total liver cancer cases. Lack of treatment options and late diagnosis contribute to high mortality rate of HCC. In eukaryotes, translation of messenger RNA (mRNA) to protein is a key process in protein biosynthesis in which initiation of translation involves interaction of different eukaryotic translation initiation factors (eIFs), ribosome subunits and mRNAs. Eukaryotic translation initiation factor 5A (eIF5A) is one of the eIFs involved in translation initiation and eIF5A2, one of its isoforms, is upregulated in various cancers including HCC as a result of chromosomal instability, where it resides. In HCC, eIF5A2 expression is associated with adverse prognosis such as presence of tumor metastasis and venous infiltration. Based on eIF5A2 functional studies, suppressing eIF5A2 expression by short interfering RNA alleviates the tumorigenic properties of HCC cellsin vitrowhile ectopic expression of eIF5A2 enhances the aggressiveness of HCC cellsin vivoandin vitroby inducing epithelial-mesenchymal transition. In conclusion, eIF5A2 is a potential prognostic marker as well as a therapeutic target for HCC.
机译：肝细胞癌（HCC）是原发性肝恶性肿瘤，占总肝癌病例的大部分。缺乏治疗选择和晚期诊断会导致肝癌高死亡率。在真核生物中，信使RNA（mRNA）到蛋白质的翻译是蛋白质生物合成中的关键过程，其中翻译的起始涉及不同的真核翻译起始因子（eIF），核糖体亚基和mRNA的相互作用。真核翻译起始因子5A（eIF5A）是参与翻译起始的eIF之一，eIF5A2是其同种型之一，由于其染色体的不稳定性，在包括肝癌在内的各种癌症中均被上调。在HCC中，eIF5A2表达与不良预后相关，例如肿瘤转移和静脉浸润的存在。基于eIF5A2功能研究，通过短时干扰RNA抑制eIF5A2表达可减轻HCC细胞的体外致瘤特性，而eIF5A2的异位表达可通过诱导上皮-间质转化增强HCC细胞在体内和体外的侵袭性。总之，eIF5A2是潜在的预后标志物，也是肝癌的治疗靶标。

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