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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >Implementation of treatment planning in the routine clinical procedure of regional hyperthermia treatment of cervical cancer: An overview and the Rotterdam experience
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Implementation of treatment planning in the routine clinical procedure of regional hyperthermia treatment of cervical cancer: An overview and the Rotterdam experience

机译：宫颈癌区域热疗常规临床程序中治疗计划的实施：概述和鹿特丹经验

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Purpose: This manuscript provides an overview in the field of hyperthermia treatment planning (HTP) in cervical cancer. Treatment planning techniques: The workflow of an HTP assisted treatment generally consists of patient imaging, tissue segmentation, model generation, electromagnetic (EM) and thermal calculations, optimisation, and clinical implementation. A main role in HTP is played by numerical simulations, for which currently a number of software packages are available in hyperthermia. To implement these simulations, accurate applicator models and accurate knowledge of dielectric and thermal parameters is mandatory. Model validation is necessary to check if this is implemented well. In the translation from HTP models to the clinic, the main aspect is accurate representation of the actual treatment situation in the HTP models. Accurate patient positioning and organ-specific segmentation can be helpful in minimising the differences between model and clinic. Steering strategies: In the clinic, different approaches are possible: simple, i.e. target centre point (TCP) steering, often called ‘target steering’, or only pretreatment planning versus advanced, i.e. active HTP guided steering or image guided hyperthermia by non-invasive thermometry (NIT). The Rotterdam experience: To illustrate the implementation of HTP guided steering, the Rotterdam approach of complaint adaptive steering is elaborated, in which optimisation is adapted with increased constraints on tissues with heat-induced discomfort. Conclusions: Many publications on HTP show that HTP can be considered a feasible method to optimise and control a hyperthermia treatment, with the objective to enhance treatment quality and documentation. Ultimately, after overcoming the various uncertainties, this may lead to dose prescription.
机译：目的：本手稿概述了子宫颈癌的高热治疗计划（HTP）。治疗计划技术：HTP辅助治疗的工作流程通常包括患者成像，组织分割，模型生成，电磁（EM）和热计算，优化和临床实施。数值模拟在HTP中起主要作用，目前，在高温中有许多软件包可用。为了实施这些仿真，必须有精确的喷枪模型以及对电介质和热参数的准确了解。必须进行模型验证，以检查是否实施得当。从HTP模型到临床的翻译中，主要方面是HTP模型中实际治疗情况的准确表示。准确的患者定位和特定于器官的细分有助于最大程度地减少模型与临床之间的差异。指导策略：在诊所中，可以采用不同的方法：简单的目标中心点（TCP）指导，通常称为“目标指导”，或者仅是预处理计划与高级的计划，即通过无创的主动HTP指导的指导或图像指导的热疗温度计（NIT）。鹿特丹的经验：为了说明HTP引导转向的实施，阐述了鹿特丹的适应性自适应转向方法，其中对优化进行了调整，增加了对因热引起的不适感的组织的约束。结论：关于HTP的许多出版物表明，HTP被认为是优化和控制热疗治疗的可行方法，目的是提高治疗质量和记录。最终，在克服各种不确定性之后，这可能导致制定剂量处方。

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