...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia
【24h】

External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia

机译：直肠癌预后预测模型的外部验证，包括接受术前放化疗和深部区域热疗的一组患者

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: To validate a nomogram for the prediction of treatment outcomes after preoperative radiochemotherapy and surgery for locally advanced rectal cancer with a cohort of patients treated with additional deep regional hyperthermia. Patients and methods: A total of 86 patients were treated with preoperative radiochemotherapy and deep regional hyperthermia at our institution. For every patient, the 5-year probability for death, distant metastases and local failure based on a previously published nomogram were calculated and patients were divided into three risk groups. Results: Low-lying and clinically lymph node positive tumours were more frequent in the validation cohort. Five-year Kaplan–Meier estimates for overall survival (OS), distant metastases-free survival (DMFS) and local control (LC) were 87.3%, 79.9%, 95.8% (observed) and 75.5%, 71%, 90% (predicted), respectively. Discrimination between low- and high-risk groups was at a significant level for all endpoints. The c-index was 0.81 (OS), 0.67 (DMFS) and 0.92 (LC), respectively. Conclusions: The nomogram showed reasonable performance when deep regional hyperthermia is incorporated into preoperative therapy. The higher than predicted rates seen for OS and DMFS in particular in the high-risk groups warrant further prospective validation and subsequent investigation of the underlying mechanisms.
机译：目的：为了验证诺模图，以预测局部晚期直肠癌的术前放化疗和手术后的治疗结果，该队列研究人员接受了其他深部区域热疗。患者和方法：我们机构共对86例患者进行了术前放化疗和深部区域热疗。根据先前公布的列线图，为每位患者计算5年死亡，远处转移和局部衰竭的概率，并将患者分为三个风险组。结果：在验证队列中，低洼和临床上淋巴结阳性的肿瘤更为常见。五年Kaplan–Meier评估的总生存期（OS），无远处转移生存期（DMFS）和局部控制（LC）分别为87.3％，79.9％，95.8％（观察到）和75.5％，71％，90％（预测）。对于所有终点，低风险和高风险人群之间的区分程度都很高。 c指数分别为0.81（OS），0.67（DMFS）和0.92（LC）。结论：深部区域热疗合并术前治疗时，诺模图显示出合理的性能。特别是在高风险人群中，OS和DMFS的发生率高于预期，因此有必要进行进一步的前瞻性验证和对基础机制的后续研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号