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首页> 外文期刊>International Journal of Hepatology >Diagnosis of Spontaneous Bacterial Peritonitis and anIn SituHybridization Approach to Detect an “Unidentified” Pathogen
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Diagnosis of Spontaneous Bacterial Peritonitis and anIn SituHybridization Approach to Detect an “Unidentified” Pathogen

机译：自发性细菌性腹膜炎的诊断和原位杂交方法以检测“未知”病原体

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Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication in cirrhotic patients with ascites. Although identifying the pathogen(s) plays a major role in the management of infectious diseases, ascitic fluid cultures often show negative results in patients with clinical signs and symptoms of SBP, and ascitic fluid cell analyses are the gold standard method for diagnosing SBP. SBP is generally diagnosed based on an increased number of polymorphonuclear neutrophils in the ascitic fluid (>250/mm3), and the identification of the causal pathogen may not be given consideration. We newly developed anin situhybridization (ISH) method to provide early and direct evidence of bacterial infection in ascites in patients with SBP. This paper will review the diagnosis of SBP, including our novel approach with ISH method to detect bacterial DNA in SBP ascitic fluid.
机译：自发性细菌性腹膜炎（SBP）是肝硬化腹水患者的一种常见且严重的并发症。尽管确定病原体在传染病的管理中起着重要作用，但腹水培养通常在具有SBP临床症状和体征的患者中显示阴性结果，而腹水细胞分析是诊断SBP的金标准方法。通常根据腹水中多形核嗜中性粒细胞的数量增加（> 250 / mm3）来诊断SBP，并且可能不考虑确定病因。我们新开发了anin原位杂交（ISH）方法，可为SBP患者的腹水提供早期和直接的细菌感染证据。本文将回顾SBP的诊断，包括我们采用ISH方法检测SBP腹水中细菌DNA的新方法。

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