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首页> 外文期刊>International Journal of Inflammation >Resident Corneal Cells Communicate with Neutrophils Leading to the Production of IP-10 during the Primary Inflammatory Response to HSV-1 Infection
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Resident Corneal Cells Communicate with Neutrophils Leading to the Production of IP-10 during the Primary Inflammatory Response to HSV-1 Infection

机译：在对HSV-1感染的主要炎症反应过程中，常驻角膜细胞与中性粒细胞沟通，导致产生IP-10

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摘要

In this study we show that murine and human neutrophils are capable of secreting IP-10 in response to communication from the HSV-1 infected cornea and that they do so in a time frame associated with the recruitment of CD8+T cells and CXCR3-expressing cells. Cellular markers were used to establish that neutrophil influx corresponded in time to peak IP-10 production, and cellular depletion confirmed neutrophils to be a significant source of IP-10 during HSV-1 corneal infection in mice. A novelex vivomodel for human corneal tissue infection with HSV-1 was used to confirm that cells resident in the cornea are also capable of stimulating neutrophils to secrete IP-10. Our results support the hypothesis that neutrophils play a key role in T-cell recruitment and control of viral replication during HSV-1 corneal infection through the production of the T-cell recruiting chemokine IP-10.
机译：在这项研究中，我们表明，鼠类和人类中性粒细胞能够响应被HSV-1感染的角膜的通讯而分泌IP-10，并且它们在与募集CD8 + T细胞和表达CXCR3相关的时间范围内细胞。使用细胞标记物来确定中性粒细胞的流入在时间上对应于IP-10的峰值产生，并且细胞耗竭证实中性粒细胞是小鼠HSV-1角膜感染期间IP-10的重要来源。用于人类角膜组织感染HSV-1的Novelex体内模型用于确认驻留在角膜中的细胞也能够刺激嗜中性粒细胞分泌IP-10。我们的结果支持以下假设：嗜中性粒细胞通过产生T细胞募集趋化因子IP-10在HSV-1角膜感染期间在T细胞募集和病毒复制的控制中起关键作用。

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