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首页> 外文期刊>International Journal of Hepatology >Non-Invasive Radiofrequency-Induced Targeted Hyperthermia for the Treatment of Hepatocellular Carcinoma
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Non-Invasive Radiofrequency-Induced Targeted Hyperthermia for the Treatment of Hepatocellular Carcinoma

机译：非侵入性射频诱导靶向热疗治疗肝细胞癌

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Targeted biological therapies for hepatocellular cancer have shown minimal improvements in median survival. Multiple pathways to oncogenesis leading to rapid development of resistance to such therapies is a concern. Non-invasive radiofrequency field-induced targeted hyperthermia using nanoparticles is a radical departure from conventional modalities. In this paper we underscore the need for innovative strategies for the treatment of hepatocellular cancer, describe the central paradigm of targeted hyperthermia using non-invasive electromagnetic energy, review the process of characterization and modification of nanoparticles for the task, and summarize data from cell-based and animal-based models of hepatocellular cancer treated with non-invasive RF energy. Finally, future strategies and challenges in bringing this modality from bench to clinic are discussed.
机译：肝细胞癌的靶向生物疗法在中位生存率方面仅显示出最小的改善。导致对这种疗法的抗性快速发展的致癌作用的多种途径是一个问题。使用纳米颗粒的非侵入性射频场诱导的靶向热疗与传统方法完全不同。在本文中，我们强调了对治疗肝细胞癌的创新策略的需求，描述了使用无创电磁能靶向热疗的核心范例，审查了纳米粒子表征和修饰过程的任务，并总结了细胞数据非侵入性射频能量治疗的肝细胞癌的基于模型和基于动物的模型。最后，讨论了将这种模式从临床应用到临床的未来策略和挑战。

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