...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Hepatology >NCX 1000 Alone or in Combination with Vitamin E Reverses Experimental Nonalcoholic Steatohepatitis in the Rat Similarly to UDCA
【24h】

NCX 1000 Alone or in Combination with Vitamin E Reverses Experimental Nonalcoholic Steatohepatitis in the Rat Similarly to UDCA

机译：与UDCA相似，单独或与维生素E组合使用NCX 1000可逆转大鼠实验性非酒精性脂肪性肝炎

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We explored the therapeutic effect of NCX 1000, a derivative of ursodeoxycholic acid (UDCA) with nitric oxide (NO) donating properties, alone or in combination with vitamin E, in an experimental model of NASH in the rat.Methods. A control group was fed a standard liquid diet (Control), and the NASH groups were fed a high-fat liquid diet for 12 weeks without (NASH) or with simultaneous daily gavage with either NCX 1000 at 15 or 30 mg/kg (N15 and N30, resp.), or N15 plus vitamin E 100 mg/kg (N15  + VitE) for the last 6 weeks; UDCA 17.2 mg/kg was used as a reference.Results. NASH rats developed all key features of the disease. Treatments with N30 improved liver histology, decreased lipid peroxidation, and completely suppressed increases in LDH release, plasma insulin, and TNF-α. It also decreasedO2∙-release and returned liver weight and glutathione back to normal. All effects were similar to the reference treatment, UDCA. The N15 treatment was less efficient than the N30 group, but became comparable to the latter when combined to vitamin E.Conclusion. Our study demonstrates that NCX 1000 has potent cytoprotective, antioxidant, and hypoinsulinemic properties that can be enhanced by combination with vitamin E.
机译：我们探索了NCX 1000（一种熊去氧胆酸（UDCA）具有一氧化氮（NO）捐赠特性的衍生物）单独或与维生素E结合在大鼠NASH实验模型中的治疗作用。对照组接受标准流质饮食（对照组），NASH组接受高脂流质饮食12周，不使用（NASH）或同时每日灌胃，NCX 1000剂量为15或30μmg/ kg（N15）以及最后30周的N30）或N15加上100毫克/公斤的维生素E（N15 + VitE）;以UDCA 17.2mg / kg为参考。 NASH大鼠发展了该疾病的所有关键特征。 N30的治疗改善了肝脏组织学，降低了脂质过氧化作用，并完全抑制了LDH释放，血浆胰岛素和TNF-α的增加。它还降低了O2∙释放，并使肝脏重量和谷胱甘肽恢复正常。所有效果均与参考疗法UDCA相似。 N15治疗的效率不及N30组，但与维生素E结合使用时可与后者媲美。我们的研究表明，NCX 1000具有有效的细胞保护，抗氧化剂和降血脂特性，可通过与维生素E结合使用来增强。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号