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首页> 外文期刊>International Journal of Hepatology >Treatment of Liver Metastases in Patients with Neuroendocrine Tumors: A Comprehensive Review
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Treatment of Liver Metastases in Patients with Neuroendocrine Tumors: A Comprehensive Review

机译：神经内分泌肿瘤患者肝转移的治疗：综述

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摘要

Patients diagnosed with Neuroendocrine Tumors (NET) often are also diagnosed with Neuroendocrine Liver Metastases (NLM) during the course of their disease. NLM can cause significant morbidity and mortality, oftentimes much more than compared to patients with NET. Treatment options have been limited in the past, focusing on surgical resections, for which only a minority of patients are candidates. However, developments of new treatment modalities have progressed rapidly and patients with NLM now have significantly more options, including surgical-directed therapies; liver-directed therapies; and nonsurgical, non-liver-directed therapies. This review provides information about the roles of hepatic resection, orthotopic liver resection, radiofrequency ablation, hepatic artery embolization and hepatic artery chemoembolization, hepatic artery radioembolization and selective internal radiation therapy, peptide receptor radionuclide therapy, systemic chemotherapy, biotherapies including somatostatin analogs and interferon-α, vascular endothelial growth factor and mTOR targets, and microRNA-regulated pathways. Given these new options, the clinician can tailor therapy specific to the patient diagnosed with NLM, thereby giving the patient the best possible chance of prolonged survival.
机译：诊断为神经内分泌肿瘤（NET）的患者在疾病过程中也经常被诊断为神经内分泌肝转移瘤（NLM）。 NLM可以导致显着的发病率和死亡率，通常比NET患者要高得多。过去，治疗选择受到限制，仅侧重于手术切除，只有少数患者可以选择。但是，新治疗方式的发展迅速，NLM患者现在有更多选择，包括手术指导疗法。肝定向疗法;以及非手术，非肝脏导向疗法。这篇综述提供了有关肝切除，原位肝切除，射频消融，肝动脉栓塞和肝动脉化学栓塞，肝动脉放射栓塞和选择性内部放射疗法，肽受体放射性核素疗法，全身化学疗法，包括生长抑素类似物和干扰素的生物疗法的作用的信息。 α，血管内皮生长因子和mTOR靶标以及microRNA调控的途径。有了这些新的选择，临床医生可以针对诊断为NLM的患者量身定制治疗方案，从而为患者提供延长生存期的最佳机会。

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