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首页> 外文期刊>International Journal of Heart Rhythm >Effect of transcatheter closure of secundum atrial septal defect on cardiac electric remodeling
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Effect of transcatheter closure of secundum atrial septal defect on cardiac electric remodeling

机译：经导管封堵房间隔缺损对心脏电重构的影响

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Purpose: This study aimed to investigate the intermediate- and short-term effects of transcatheter secundum atrial septal defect (ASD) closure on cardiac electric remodeling in children and adults. Methods: Fifty patients with secundum ASD referred for possible transcatheter device closure were subjected to history taking, proper physical examination, electrocardiographic assessment, and transthoracic echocardiographic examination and were evaluated before the ASD closure, 1 day, 3 months, and 6 months after closure. Results: During the 6-month follow-up, electrocardiographic parameters of remodeling were improved. P dispersion decreased from 49.73 ± 9.01 ms to 30.53 ± 5.08 ms (P = 0.004), QT dispersion decreased from 67.60 ± 5.31 to 51.13 ± 5.73 ms (P = 0.003), QRS duration decreased from 134.40 ± 4.97 ms to 116.20 ± 3.47 ms (P = 0.002), and PR interval decreased from 188.87 ± 6.06 ms to 168.00 ± 6.16 ms (P = 0.002). Electric remodeling was associated with remodeling of the cardiac chambers. At the end of follow-up, the right ventricular (RV) end-diastolic dimension decreased from 25.67 ± 5.50 mm to 17.80 ± 2.70 mm (P = 0.001) the left ventricular end-diastolic dimension increased from 33.17 ± 6.44 mm to 37.53 ± 5.15 mm (P = 0.002), mean pulmonary artery pressure decreased from 16.97 ± 3.37 mmHg to 9.22 ± 1.37 mmHg (P = 0.000), and RV systolic pressure decreased from 30.77 ± 4.69 mmHg to 18.8 ± 2.11 mmHg. After 6 months, 93.3% of the patients had normal RV size. Conclusion: Transcatheter ASD device closure leads to a significant improvement in the right-sided chambers' dimension and function and can reverse electrical changes in atrial and ventricular myocardium in children and adults after correcting hemodynamic status in short- and intermediate-term follow-up.
机译：目的：本研究旨在探讨经导管secundum房间隔缺损（ASD）闭合对儿童和成人心脏电重构的中期和短期影响。方法：对50名可能经导管置入术治疗的继发性ASD患者进行了病史检查，适当的体格检查，心电图评估和经胸超声心动图检查，并在ASD关闭前，关闭后1、3个月和6个月进行了评估。结果：在6个月的随访期间，心电图重塑参数得到改善。 P离散度从49.73±9.01毫秒减少至30.53±5.08毫秒（P = 0.004），QT离散度从67.60±5.31减少至51.13±5.73 ms（P = 0.003），QRS持续时间从134.40±4.97毫秒减少至116.20±3.47毫秒（P = 0.002），PR间隔从188.87±6.06 ms减少到168.00±6.16 ms（P = 0.002）。电重构与心腔重构相关。随访结束时，右心室舒张末期尺寸从25.67±5.50 mm减小到17.80±2.70 mm（P = 0.001），左心室舒张末期尺寸从33.17±6.44 mm增加到37.53± 5.15毫米（P = 0.002），平均肺动脉压力从16.97±3.37毫米汞柱降至9.22±1.37毫米汞柱（P = 0.000），右室收缩压从30.77±4.69毫米汞柱降至18.8±2.11毫米汞柱。 6个月后，93.3％的患者RV大小正常。结论：经导管ASD装置闭合可显着改善右侧腔室的尺寸和功能，并可在短期和中期随访中纠正血液动力学状态后逆转儿童和成人心房和心室心肌的电变化。

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