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首页> 外文期刊>International Journal of Impotence Research >Efficacy of a novel water-soluble curcumin derivative versus sildenafil citrate in mediating erectile function
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Efficacy of a novel water-soluble curcumin derivative versus sildenafil citrate in mediating erectile function

机译：新型水溶性姜黄素衍生物与枸sil酸西地那非在介导勃起功能中的功效

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摘要

The present study was conducted to assess the efficacy of a novel curcumin derivative (NCD) versus sildenafil citrate in erectile signaling. The study was conducted on 10 control male rats and 50 diabetic male rats divided into the following groups: diabetic, curcumin, NCD, sildenafil and NCD combined with sildenafil. Cavernous tissue (CC) gene expression levels of heme oxygenase (HO)-1, Nrf2, NF-κβ and p38, enzyme activities of HO and nitric oxide synthase (NOS), cyclic guanosine monophosphate (cGMP) and intracavernosal pressure (ICP) were assessed. Results showed that 12 weeks after induction of diabetes, erectile dysfunction was confirmed by the significant decrease in ICP, a significant decrease in cGMP, NOS, HO enzyme activities, a significant decrease in HO-1 gene and a significant elevation of NF-κβ, p38 genes. Administration of all therapeutic interventions led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in HO-1 and Nrf2 gene expression, and a significant decrease in NF-κβ, p38 gene expression. NCD or its combination with sildenafil showed significant efficacy and more prolonged duration of action. In conclusion, NCD could enhance erectile function with more efficacy and more prolonged duration of action.
机译：进行本研究以评估新型姜黄素衍生物（NCD）与枸sil酸西地那非在勃起信号传导中的功效。该研究在10只对照组雄性大鼠和50只糖尿病雄性大鼠中进行，分为以下组：糖尿病，姜黄素，NCD，西地那非和NCD联合西地那非。血红素加氧酶（HO）-1，Nrf2，NF-κβ和p38的海绵状组织（CC）基因表达水平，HO和一氧化氮合酶（NOS）的酶活性，环鸟苷单磷酸（cGMP）和海绵体腔内压（ICP）为评估。结果显示，诱发糖尿病后12周，ICP显着下降，cGMP，NOS，HO酶活性显着下降，HO-1基因显着下降和NF-κβ显着升高证实了勃起功能障碍， p38基因。给予所有治疗性干预措施均导致ICP，cGMP水平显着升高，HO-1和NOS酶显着增加，HO-1和Nrf2基因表达显着增加以及NF-κβ，p38基因显着下降表达。 NCD或其与西地那非的组合显示出显着的疗效，并且作用时间更长。总之，NCD可以增强勃起功能，具有更高的疗效和更长的作用时间。

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