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首页> 外文期刊>International Journal of Infection Control >Pattern of surgical antibiotic prophylaxis in a tertiary care teaching hospital in India
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Pattern of surgical antibiotic prophylaxis in a tertiary care teaching hospital in India

机译：印度三级教学医院的外科手术抗生素预防模式

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Appropriate antibiotic prophylaxis can reduce the risk of postoperative wound infections, but misuse and overuse of antimicrobials increases both the cost and the selection pressure favoring the emergence of resistant bacteria. Our main objective was to study the pattern of prophylactic antibiotics in different surgeries in a large tertiary care teaching hospital. A total of hundred patients undergoing surgery, admitted under various hospital departments were enrolled in this prospective observational study. Pretested proforma which included information on patient characteristics, choice of antimicrobial agents as well as their route, timing and total duration of administration were completed. Also the appropriateness of antibiotic prophylaxis was assessed as per standard guidelines. It was found that the third generation cephalosporins were the most commonly prescribed class of antibiotics. Although only 67 percent cases required prophylaxis, it was administered in 86 percent of procedures, being unjustified in 19 % of cases. Mean timing of administration of antibiotics was 3.22 ± 1.03 hours prior to surgery and the patients received post operative antibiotics for a mean duration of 5 days during their stay in the hospital. Thus, surgical prophylaxis was inappropriate in terms of choice of agent, timing of administration as well as the total duration of prescription in majority of the cases. Interventions are warranted to promote the development, dissemination and adoption of evidence based guidelines for antimicrobial prophylaxis.
机译：适当的抗生素预防可以降低术后伤口感染的风险，但是滥用和过度使用抗菌药物会增加成本和选择压力，从而有利于耐药菌的出现。我们的主要目的是研究一家大型三级护理教学医院不同手术中的预防性抗生素模式。这项前瞻性观察研究共纳入了各医院科室收治的数百名接受手术的患者。预先测试的形式，包括有关患者特征，抗微生物剂的选择以及它们的途径，时机和总给药时间的信息已完成。还根据标准指南评估了抗生素预防的适当性。发现第三代头孢菌素是最常用的抗生素类。尽管只有67％的病例需要预防，但在86％的过程中进行了预防，而在19％的病例中不合理。手术前抗生素的平均施用时间为手术前3.22±1.03小时，患者在住院期间接受术后抗生素的平均持续时间为5天。因此，在大多数情况下，就药物的选择，给药时间以及处方总时长而言，手术预防是不合适的。有必要采取干预措施来促进抗菌药物预防指南的发展，传播和采用。

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