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首页> 外文期刊>International Journal of Infection Control >Faecal carriage of Extended Spectrum Beta-lactamase producing Escherichia coli and Klebsiella Pneumoniae in children from the community of Kwadedangendlale, KwaZulu-Natal, South Africa.
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Faecal carriage of Extended Spectrum Beta-lactamase producing Escherichia coli and Klebsiella Pneumoniae in children from the community of Kwadedangendlale, KwaZulu-Natal, South Africa.

机译：南非夸祖鲁-纳塔尔省夸德当根德拉（Kwadedangendlale）社区儿童的粪便中携带产生超广谱β-内酰胺酶的大肠杆菌和肺炎克雷伯菌。

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Infections caused by ESBL producing organisms have been described as an emerging public health problem in many parts of the world. Traditionally, ESBL producing organisms have been associated with hospital acquired infections. Recent studies have shown an increase in these infections within the community. Faecal carriage is a significant reservoir of ESBL producing bacteria in the community and colonization of the intestinal tract has been shown to precede infection. Faecal carriage of ESBL producing organisms in children from the community, in Africa has been poorly studied. Stool samples were collected from 300 children from Kwadedangendlale, KwaZulu-Natal, South Africa, during the period July 2011 to May 2012. Samples were inoculated onto MacConkey agar. All Gram negative bacteria cultured underwent identification and antimicrobial susceptibility testing on the Vitek 2. Isolates reported as ESBL positive, underwent confirmatory testing by the CLSI recommended combined disk diffusion method. All duplicates were removed. We report faecal carriage of ESBL producing enterobacteriaceae in 4.7% (14/ 300) of children from the community in KwaZulu-Natal, South Africa. ESBL producing K. pneumoniae (3.7%) was the predominant isolate, with ESBL producing E coli being detected in 1% of children. This is the largest study to report on faecal carriage of ESBL producing enterobacteriaceae in children from the community in Africa. There is an urgent need to perform regular surveillance of ESBL producing bacteria in the community. This information is needed in order to direct the appropriate use of antimicrobials for empirical treatment of community acquired infections.
机译：在世界许多地方，由产生ESBL的生物引起的感染已被描述为正在出现的公共卫生问题。传统上，产生ESBL的生物与医院获得性感染有关。最近的研究表明社区内这些感染的增加。粪便运输是社区中大量ESBL产生细菌的储库，肠道菌落已显示出感染之前。在非洲社区儿童中粪便携带ESBL的生物体的研究很少。在2011年7月至2012年5月期间，从南非夸祖鲁-纳塔尔省夸瓦当丹德尔（Kwadedangendlale）的300名儿童中收集了粪便样本。将样本接种到MacConkey琼脂上。所有培养的革兰氏阴性细菌均经过Vitek 2鉴定和抗菌药敏试验。报告为ESBL阳性的分离株，通过CLSI建议的组合圆盘扩散法进行确认试验。所有重复项均被删除。我们报告在南非夸祖鲁-纳塔尔省的社区中，有4.7％（14/300）的儿童粪便运输产生ESBL的肠杆菌科。产ESBL的肺炎克雷伯菌（3.7％）是主要分离株，在1％的儿童中检测到产ESBL的大肠杆菌。这是有关非洲社区儿童ESBL产肠杆菌科细菌粪便运输的最大研究报告。迫切需要在社区中定期监测产生ESBL的细菌。需要这些信息，以指导适当地使用抗生素进行社区获得性感染的经验治疗。

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