Preface for the Special Issue

Yossi Cohen

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Preface for the Special Issue

机译：特刊前言

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Plasma cells are terminally differentiated B cells whichnormally secret immunoglobulins. The group of plasmacell disorders consistsof several sub-categories includingmonoclonal gammopathy of unknown significance(MGUS), primary amyloidosis, the polyneuropathy,organomegaly, endocrinopathy, monoclonal gammopathy,and skin changes (POEMS) syndromeas well as multiplemyeloma (MM). The latter category is subdivided intosymptomatic versus asymptomatic myeloma and is alsostratified by clinical prognostic scores such as the oldDurie-Salmon classification and the newer internationalscoring system (ISS), as well as according to reproduciblechromosomal abnormalities and more recently also byhigh versus low-risk gene expression profile (GEP). Theclinical manifestations of transformed plasma cells aremainly derived from the local effects of the tumor cellsproper and from the impact of the circulating monoclonalimmunoglobulins.

机译：浆细胞是终末分化的B细胞，其通常分泌免疫球蛋白。浆细胞疾病的组包括几个子类别，包括重要性不明的单克隆球菌病（MGUS），原发性淀粉样变性，多发性神经病，有机肥大，内分泌病，单克隆球菌病和皮肤变化（POEMS）综合征以及多发性骨髓瘤（MM）。后一类又分为有症状的和无症状的骨髓瘤，并且还根据临床预后评分，例如旧的Durie-Salmon分类和较新的国际评分系统（ISS），以及可再现的染色体异常，以及最近的高风险和低风险基因表达，进行了分类。配置文件（GEP）。转化浆细胞的临床表现主要来自肿瘤细胞适当的局部作用和循环单克隆免疫球蛋白的作用。

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《International Journal of Hematological Disorders》 |2014年第1a期|共1页
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Yossi Cohen;
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中图分类血液及淋巴系疾病;
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