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首页> 外文期刊>International Journal of Gerontology >Impact of Moderate to Severe Chronic Kidney Disease for Long Term Survival of Implantable Cardioverter Defibrillator Patients in Taiwan
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Impact of Moderate to Severe Chronic Kidney Disease for Long Term Survival of Implantable Cardioverter Defibrillator Patients in Taiwan

机译：台湾中度至重度慢性肾脏疾病对植入式心脏复律除颤器患者长期存活的影响

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Summary Background The influence of renal impairment on long-term mortality in Taiwanese patients with an ICD was uncertain. The aim of our study was to examine the impact of moderate to severe CKD on outcome in patients with ICD implantation for secondary prevention in Taiwan. Methods From 2005 to 2013, patients who underwent ICD implantation who were survivors of sudden cardiac arrest or unstable hemodynamics due to ventricular arrhythmia at a single medical center were included in this registry. We divided the patients into two groups, group 1 with estimated glomerular filtration rates (eGFRs) of ≥60?mL/(min?1.73?cm2) and group 2 with eGFRs of 2). The clinical end point was defined as the occurrence of all-cause mortality during the follow-up. Results 84 consecutive patients were enrolled in this registry. The mean age of the patients was 62.7?±?13.2 years, and 54.8% were male. The patients of group 2 were older (mean age: 66.4 vs. 56.2 years) and had worse renal function (42?±?12.3 vs. 89.0?±?18.5?mL/(min?1.73?cm2)). They more often had hypertension (56.5% vs. 31.6%), diabetes mellitus (52.2% vs. 15.8%), and previous hospitalization for congestive heart failure as comorbidity (71.7% vs. 28.9%). During the mean follow-up duration of 952 days, 19 patients (22.6%) died. After adjustment for the parameters, eGFRs 2) was an independent predictor of all-cause mortality (AHR:6.21, 95%CI:1.28–30.06, P?=?0.02). Conclusion Moderate to severe CKD is independently associated with increased mortality in Taiwanese patients who underwent ICD implantation for secondary prevention.
机译：总结背景肾功能不全对台湾ICD患者长期死亡率的影响尚不确定。我们研究的目的是检验台湾中度至重度CKD对ICD植入患者二级预后的影响。方法2005年至2013年间，在一个医疗中心将因ICD植入而因室性心律失常而导致心脏骤停或血流动力学不稳定的幸存者纳入本研究。我们将患者分为两组，第一组的肾小球滤过率（eGFRs）估计≥60？mL /（min？1.73？cm 2 ），第二组的eGFRs为2 ）。临床终点定义为随访期间全因死亡率的发生。结果该登记处连续登记了84名患者。患者的平均年龄为62.7±13.2岁，男性为54.8％。第2组患者年龄较大（平均年龄：66.4 vs. 56.2岁），肾功能较差（42？±？12.3 vs. 89.0？±？18.5？mL /（min？1.73？cm 2 ）。他们更常患有高血压（56.5％vs. 31.6％），糖尿病（52.2％vs. 15.8％）以及先前因充血性心力衰竭合并症住院（71.7％vs. 28.9％）。在952天的平均随访期间，有19名患者（22.6％）死亡。调整参数后，eGFRs 2 是全因死亡率的独立预测因子（AHR：6.21，95％CI：1.28-30.06，P？=？0.02）。结论中度至重度CKD与接受ICD植入二级预防的台湾患者死亡率增加独立相关。

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