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首页> 外文期刊>International Journal of Gerontology >Clinical Association of Cystatin C and Atrial Fibrillation in Chinese Elderly
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Clinical Association of Cystatin C and Atrial Fibrillation in Chinese Elderly

机译：胱抑素C与中国老年人房颤的临床关联

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Background: Atrial fibrillation (AF) is associated with inflammation. Cystatin C is not only an inflammatory marker but also an independent predictor of cardiovascular events. We sought to investigate the relationship between serum levels of cystatin C and AF in the elderly. Methods: This study retrospectively investigated 211 paroxysmal and persistent AF patients, 225 permanent AF patients (age >= 60 years), and 204 healthy elderly people in the control group for cystatin C, high-sensitivity C reactive protein (hsCRP), white blood cell count, biochemical indicators, and echocardiography. Results: Compared with the control group, AF groups had higher values for body mass index, systolic blood pressure, fasting blood glucose, estimated glomerular filtration rate, hsCRP, cystatin C, left atrial diameter, and left ventricular diameter but lower values of left ventricular ejection fraction (p < 0.05). After adjustment, correlation analysis showed that the serum level for cystatin C was closely related to blood urea nitrogen, creatinine, and left atrial diameter, the correlation coefficients were, respectively, 0.490 mg/L, 0.547 mg/L, and 0.521 mg/L (all p < 0.05), but negatively associated with estimated glomerular filtration rate (r = -0.702, p < 0.001) in AF groups. Multivariable regression analysis showed the hsCRP, cystatin C, left atrial diameter, and left ventricular ejection fraction entered finally into the regression equation (cystatin C, odds ratio: 1.93, 95% confidence interval 1.12-3.07, p = 0.010). Conclusion: The serum levels of cystatin C showed a significant correlation with AF, which indicates that increased cystatin C is related to the incidence of AF in older patients.
机译：背景：房颤（AF）与炎症相关。胱抑素C不仅是炎症标记，还是心血管事件的独立预测因子。我们试图调查老年人血清胱抑素C水平与房颤之间的关系。方法：本研究回顾性分析了211例阵发性和持续性AF患者，225例永久性AF患者（年龄> = 60岁）和204例健康老年人的胱抑素C，高敏C反应蛋白（hsCRP），白血球细胞计数，生化指标和超声心动图。结果：与对照组相比，AF组的体重指数，收缩压，空腹血糖，估计的肾小球滤过率，hsCRP，胱抑素C，左心房直径和左心室直径值较高，但左心室值较低射血分数（p <0.05）。校正后，相关分析表明，胱抑素C的血清水平与血尿素氮，肌酐和左心房直径密切相关，相关系数分别为0.490 mg / L，0.547 mg / L和0.521 mg / L。 （所有p <0.05），但与AF组的肾小球滤过率估计值呈负相关（r = -0.702，p <0.001）。多变量回归分析显示，hsCRP，胱抑素C，左心房直径和左心室射血分数最终进入了回归方程（胱抑素C，优势比：1.93，95％置信区间1.12-3.07，p = 0.010）。结论：血清胱抑素C水平与房颤呈显着相关性，表明血浆胱抑素C升高与老年患者房颤发生率有关。

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