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首页> 外文期刊>International Journal of Medical Sciences >Clinicopathological Implications of Human Papilloma Virus (HPV) L1 Capsid Protein Immunoreactivity in HPV16-Positive Cervical Cytology
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Clinicopathological Implications of Human Papilloma Virus (HPV) L1 Capsid Protein Immunoreactivity in HPV16-Positive Cervical Cytology

机译：HPV16阳性宫颈细胞学中人乳头瘤病毒（HPV）L1衣壳蛋白免疫反应性的临床病理学意义

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Background: The objective of this study was to investigate the expression of human papilloma virus (HPV) L1 capsid protein in abnormal cervical cytology with HPV16 infection and analyze its association with cervical histopathology in Korean women. Material and Methods: We performed immunocytochemistry for HPV L1 in 475 abnormal cervical cytology samples from patients with HPV16 infections using the Cytoactiv? HPV L1 screening set. We investigated the expression of HPV L1 in cervical cytology samples and compared it with the results of histopathological examination of surgical specimens. Results: Of a total of 475 cases, 188 (39.6%) were immunocytochemically positive and 287 (60.4%) negative for HPV L1. The immunocytochemical expression rates of HPV L1 in atypical squamous cells of unknown significance (ASCUS), low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), and cancer were 21.8%, 59.7%, 19.1%, and 0.0%, respectively. LSIL exhibited the highest rate of HPV L1 positivity. Of a total of 475 cases, the multiple-type HPV infection rate, including HPV16, in HPV L1-negative cytology samples was 27.5%, which was significantly higher than that in HPV L1-positive cytology samples (p = 0.037). The absence of HPV L1 expression in ASCUS and LSIL was significantly associated with high-grade (≥cervical intraepithelial neoplasia [CIN] 2) than low-grade (≤CIN1) histopathology diagnoses (p p > 0.05). On the other hand, among 188 HPV L1-positive cases, 30.6% of multiple-type HPV infections showed high-grade histopathology diagnoses (≥CIN3), significantly higher than the percentage of HPV16 single infections (8.6%) (p = 0.0004) Conclusions: Our study demonstrates that the expression of HPV L1 is low in advanced dysplasia. Furthermore, the absence of HPV L1 in HPV16-positive low-grade cytology (i.e., ASCUS and LSIL) is strongly associated with high-grade histopathology diagnoses. The multiplicity of HPV infections may have an important role in high-grade histopathology diagnoses (≥CIN3) in HPV L1-positive cases.
机译：背景：本研究的目的是调查人乳头瘤病毒（HPV）L1衣壳蛋白在HPV16感染的异常宫颈细胞学中的表达，并分析其与韩国女性宫颈组织病理学的关系。材料与方法：我们使用Cytoactiv ？ HPV L1筛查设备对475例HPV16感染患者的异常宫颈细胞学样本中的HPV L1进行了免疫细胞化学分析。我们调查了HPV L1在宫颈细胞学样本中的表达，并将其与手术样本的组织病理学检查结果进行了比较。结果：在总共475例病例中，HPV L1免疫细胞化学阳性188例（39.6％），阴性（287）（60.4％）。 HPV L1在非典型意义的非典型鳞状细胞（ASCUS），低度鳞状上皮内病变（LSIL），高度鳞状上皮内病变（HSIL）和癌症中的免疫细胞化学表达率为21.8％，59.7％，19.1％，和0.0％。 LSIL表现出最高的HPV L1阳性率。在总共475例病例中，HPV L1阴性细胞学样本中包括HPV16在内的多型HPV感染率是27.5％，显着高于HPV L1阳性细胞学样本（p = 0.037）。与低度（≤CIN1）组织病理学诊断相比，ASCUS和LSIL中HPV L1表达的缺乏与高度（≥宫颈上皮内瘤变[CIN] 2）显着相关（p p> 0.05）。另一方面，在188例HPV L1阳性病例中，有30.6％的多型HPV感染显示出高级别的组织病理学诊断（≥CIN3），显着高于HPV16单一感染的百分比（8.6％）（p = 0.0004）结论：我们的研究表明，HPV L1在晚期发育异常中的表达较低。此外，HPV16阳性低级细胞学（即ASCUS和LSIL）中不存在HPV L1与高级组织病理学诊断密切相关。在HPV L1阳性病例中，多种HPV感染可能在高级组织病理学诊断（≥CIN3）中起重要作用。

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