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首页> 外文期刊>International Journal of Medical Sciences >Circular RNAs: Novel Promising Biomarkers in Ocular Diseases
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Circular RNAs: Novel Promising Biomarkers in Ocular Diseases

机译：环状RNA：眼病中新的有前途的生物标志物

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Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs produced by back-splicing. They are found to be expressed in eukaryotic cells and play certain roles in various cellular functions, including fibrosis, cell proliferation, differentiation, apoptosis and angiogenesis. Dysregulated circRNAs are found in several human disorders including, malignancy, vascular, inflammatory as well as nervous diseases. Although, increasing evidence suggests that circRNAs may also contribute in different ocular diseases, the outline of circRNAs in ocular diseases remains obscure. In this review we consider the current state of knowledge regarding the potential role and underlying mechanism of circRNAs in ocular diseases including pterygium, age-related cataract, glaucoma, diabetic retinopathy, retinoblastoma, retinal vascular dysfunction and hyperhomocysteinemia induced ocular diseases, emphasizing that circRNAs could be promising biomarkers for the diagnosis and prognosis evaluation. Future circRNAs-targeted intervention may become a novel therapeutic tool for the treatment of ocular diseases.
机译：环状RNA（circRNA）是一类通过反向剪接产生的新型内源非编码RNA。发现它们在真核细胞中表达，并在各种细胞功能中发挥某些作用，包括纤维化，细胞增殖，分化，凋亡和血管生成。 circRNA失调存在于多种人类疾病中，包括恶性肿瘤，血管疾病，炎性疾病和神经疾病。尽管越来越多的证据表明circRNA也可能在不同的眼科疾病中起作用，但是circRNA在眼科疾病中的轮廓仍然不清楚。在这篇综述中，我们考虑了关于circRNA在眼科疾病（包括翼状role肉，年龄相关性白内障，青光眼，糖尿病性视网膜病变，视网膜母细胞瘤，视网膜血管功能障碍和高同型半胱氨酸血症引起的眼科疾病）的潜在作用和潜在机制方面的最新知识。成为诊断和预后评估的有前途的生物标志物。靶向circRNAs的未来干预可能会成为治疗眼部疾病的新型治疗工具。

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