Muscle Extracellular Matrix Scaffold Is a Multipotent Environment

Paola Aulino; Alessandra Costa; Ernesto Chiaravalloti; Barbara Perniconi; Sergio Adamo; Dario Coletti; Massimo Marrelli; Marco Tatullo; Laura Teodori

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Muscle Extracellular Matrix Scaffold Is a Multipotent Environment

机译：肌肉细胞外基质支架是一个多能的环境。

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The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the host bone, thus highlighting the importance of the environment in directing cell homing and differentiation. These results unveil the multipotency of MAS and point to the potential of this new technique as a valuable tool in musculo-skeletal tissue regeneration.

机译：支架的多能性是一个新概念。在鼠模型中，在胫骨前/胫骨和咬肌/下颌骨的界面处植入的骨骼肌无细胞支架（MAS）被宿主肌肉附近的肌细胞和宿主骨骼附近的骨-软骨组织定殖。环境在指导细胞归巢和分化中的重要性。这些结果揭示了MAS的多能性，并指出了这项新技术作为肌肉骨骼组织再生中有价值的工具的潜力。

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《International Journal of Medical Sciences》 |2015年第4期|共5页
作者
Paola Aulino; Alessandra Costa; Ernesto Chiaravalloti; Barbara Perniconi; Sergio Adamo; Dario Coletti; Massimo Marrelli; Marco Tatullo; Laura Teodori;
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中图分类医药、卫生;
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1. In Vitro Mesenchymal Trilineage Differentiation and Extracellular Matrix Production by Adipose and Bone Marrow Derived Adult Equine Multipotent Stromal Cells on a Collagen Scaffold [J] . Lin Xie, Nan Zhang, Anna Marsano, Stem Cell Reviews and Reports . 2013,第6期

机译：脂肪和骨髓衍生的成年马多能基质细胞在胶原蛋白支架上的体外间充质三联分化和细胞外基质的产生。
2. In Vitro Mesenchymal Trilineage Differentiation and Extracellular Matrix Production by Adipose and Bone Marrow Derived Adult Equine Multipotent Stromal Cells on a Collagen Scaffold [J] . Lin Xie, Nan Zhang, Anna Marsano, Stem cell reviews and Reports . 2013,第6期

机译：脂肪和骨髓衍生的成人马多能基质细胞在胶原蛋白支架上的体外间充质三联分化和细胞外基质的产生。
3. Smooth muscle α-actin and calponin expression and extracellular matrix production of human coronary artery smooth muscle cells in 3D scaffolds [J] . GrenierS., SandigM., MequanintK. Tissue engineering, Part A . 2009,第10期

机译：3D支架中人冠状动脉平滑肌细胞的平滑肌α-肌动蛋白和钙蛋白表达及细胞外基质产生
4. Promotion of extracellular matrix deposition by human vascular smooth muscle cells and monocytes within a biodegradable polyurethane scaffold [C] . Xiaoqing Zhang, Kyle Battiston, Rosalind Labow, World biomaterials congress . 2016

机译：通过可生物降解的聚氨酯支架中的人血管平滑肌细胞和单核细胞促进细胞外基质沉积
5. Bioengineering Extracellular Matrix Scaffolds for Volumetric Muscle Loss [D] . Roberts, Kevin. 2019

机译：生物工程细胞外基质支架用于体积肌肉损失
6. Muscle Extracellular Matrix Scaffold Is a Multipotent Environment [O] . Paola Aulino, Alessandra Costa, Ernesto Chiaravalloti, 1990

机译：肌肉细胞外基质支架是一个多能的环境。
7. Muscle extracellular matrix scaffold is a multipotent environment [O] . P Aulino, A Costa, E Chiaravalloti, 2015

机译：肌肉细胞外基质支架是一个多能环境

Muscle Extracellular Matrix Scaffold Is a Multipotent Environment

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