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首页> 外文期刊>International Journal of Medical Sciences >Upregulation of Heat Shock Proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in Tumour Tissues Is Associated with Poor Outcomes from HBV-Related Early-Stage Hepatocellular Carcinoma
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Upregulation of Heat Shock Proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in Tumour Tissues Is Associated with Poor Outcomes from HBV-Related Early-Stage Hepatocellular Carcinoma

机译：肿瘤组织中热休克蛋白（HSPA12A，HSP90B1，HSPA4，HSPA5和HSPA6）的上调与HBV相关的早期肝细胞癌的不良结果相关

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Background: Heat shock proteins (HSPs) are overexpressed in human hepatocellular carcinoma (HCC) tissue and correlate with aggressiveness and prognosis of HCC. Methods: Using the GSE14520 microarray expression profile from Gene Expression Omnibus, we compared HSP gene expression between tumour and non-tumour tissues and correlated this with outcomes in HCC patients. Results: We analysed 220 hepatitis B virus (HBV)-related HCC patients and 25 HSPs in this study. With the exception of HSPA4L, HSPA12A and HSPB8, members of the HSP family, including HSPH1, HSPBP1, HSPA1A, HSPA1B, HSPA1L, HSPA2, HSPA4, HSPA5, HSPA8, HSPA9, HSPAA1, HSPAB1, HSPA14, HSPB11, HSPA13, HSP90B1 and HSPBAP1, were all overexpressed in tumour tissues (all P P P = 0.02), Barcelona Clinic liver cancer (BCLC) staging (HR = 2.151, 95% CI = 1.682-2.750, P P = 0.033) and HSP90B1 (HR = 1.001, 95% CI = 1.000-1.001, P = 0.011) were negatively associated with survival of HBV-related HCC patients. Furthermore, advanced BCLC staging (HR = 1.797, 95% CI = 1.439-2.244, P P = 0.019), HSPA5 (HR = 1.0, 95% CI = 1.0-1.0, P = 0.046) and HSPA6 (HR = 1.008, 95% CI = 1.001-1.015, P = 0.021) was similarly associated with HCC recurrence. Conclusions: The expression of most HSPs was higher in tumour tissues than in non-tumour tissues. High BCLC staging scores, advanced cirrhosis and the overexpression of HSPA12A and HSP90B1 might be associated with poor survival from HCC, whereas high levels of HSPA4, HSPA5 and HSPA6 might be associated with earlier recurrence of HCC.
机译：背景：热休克蛋白（HSP）在人肝细胞癌（HCC）组织中过表达，并且与HCC的侵略性和预后相关。方法：使用来自Gene Expression Omnibus的GSE14520芯片表达谱，我们比较了肿瘤和非肿瘤组织之间的HSP基因表达，并将其与HCC患者的预后相关。结果：在本研究中，我们分析了220例与乙肝病毒（HBV）相关的HCC患者和25例HSP。除HSPA4L，HSPA12A和HSPB8外，HSP家族的成员包括HSPH1，HSPBP1，HSPA1A，HSPA1B，HSPA1L，HSPA2，HSPA4，HSPA5，HSPA8，HSPA9，HSPAA1，HSPAB1，HSPA14，HSPB11，HSPA13，HAP90B1均在肿瘤组织中过表达（所有PPP = 0.02），巴塞罗那临床肝癌（BCLC）分期（HR = 2.151，95％CI = 1.682-2.750，PP = 0.033）和HSP90B1（HR = 1.001，95％CI = 1.000-1.001，P = 0.011）与HBV相关HCC患者的生存率呈负相关。此外，高级BCLC分期（HR = 1.797，95％CI = 1.439-2.244，PP = 0.019），HSPA5（HR = 1.0，95％CI = 1.0-1.0，P = 0.046）和HSPA6（HR = 1.008，95％ CI = 1.001-1.015，P = 0.021）与HCC复发类似。结论：大多数HSPs在肿瘤组织中的表达高于非肿瘤组织。高BCLC分期评分，晚期肝硬化以及HSPA12A和HSP90B1的过度表达可能与肝癌生存不良有关，而高水平的HSPA4，HSPA5和HSPA6可能与HCC的早期复发有关。

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