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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study
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Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study

机译：一项12-14岁丹麦儿童椎间盘退变的遗传危险因素：一项人群研究

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The objective of the present study was to examine the associations between eleven putative predisposing single nucleotide polymorphisms (COL9A3, COL11A2, IL1A, IL1B, IL6 and VDR) and early disc degeneration (DD). The population consisted of 12 to 14-year-old Danish children (N=352). DD was evaluated from magnetic resonance images (MRI). We analysed the association between DD and single nucleotide polymorphisms or haplotypes using logistic regression analyses. Of the 352 children studied, 73 boys and 81 girls had no MRI changes, while 30 boys and 36 girls had lumbar DD. Among girls, IL1A rs1800587 in CT/TT compared to CC resulted in OR 2.85 [1.19-6.83]. In IL6 promoter polymorphism rs1800796, the C-allele was more frequent among the subjects with DD, OR 6.71 [1.71-26.3]. Of the IL6 haplotypes, GCG was associated with DD, OR 6.46 [1.61 – 26.0]. No associations were observed among boys. Our results suggest possible roles for IL1A and IL6 in early DD among girls.
机译：本研究的目的是检查十一种假定的易感性单核苷酸多态性（COL9A3，COL11A2，IL1A，IL1B，IL6和VDR）与早期椎间盘退变（DD）之间的关联。人口包括12至14岁的丹麦儿童（N = 352）。从磁共振图像（MRI）评估DD。我们使用逻辑回归分析分析了DD与单核苷酸多态性或单倍型之间的关联。在研究的352名儿童中，有73名男孩和81名女孩没有MRI改变，而30名男孩和36名女孩患有腰椎DD。在女孩中，与CC相比，CT / TT中的IL1A rs1800587导致OR为2.85 [1.19-6.83]。在IL6启动子多态性rs1800796中，C等位基因在DD或OR为6.71的受试者中更为常见[1.71-26.3]。在IL6单倍型中，GCG与DD或6.46 [1.61 – 26.0]相关。在男孩之间未发现关联。我们的研究结果提示IL1A和IL6在女孩早期DD中的可能作用。

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