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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Role of IGF-I, IGF-II and IGFBP-3 in lung function of males: the Caerphilly Prospective Study
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Role of IGF-I, IGF-II and IGFBP-3 in lung function of males: the Caerphilly Prospective Study

机译：IGF-I，IGF-II和IGFBP-3在男性肺功能中的作用：前科研究

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Insulin-like growth factors are peptide hormones that have an endocrine role in the development, growth and repair of human tissues including the respiratory tract. To date, only one population study exists which found positive cross-sectional associations with IGF-I and higher lung volumes. We hypothesised that higher IGF-I, IGF-II, IGFBP-3 and IGF molar ratio would be associated with better cross-sectional and longitudinal lung function. We examined cross-sectional (n=843) and prospective associations (n=717) between IGF-I, IGF-II, IGFBP-3 and IGF molar ratio with lung function in the Caerphilly Prospective Study (CaPS) from blood samples obtained around 1986, with spirometry (forced expiratory volume in one second (FEV1) and forced vital capacity (FVC)) performed in the same year and around 2003. Higher IGF molar ratio was associated with improved FEV1/FEV ratio cross-sectionally in both simple (0.007, 95% CI 0.001-0.013, P=0.02) and fully adjusted (0.001, 95% CI 0.001-0.012, P=0.03) models. With the exception of IGFBP-3 and FEV1/FVC in the simple model (0.009, 95% CI 0.001-0.018, P=0.04) all prospective associations between IGF and spirometric measures were consistent with chance. In this study of men, higher IGF molar ratio was associated with improved cross-sectional lung function, although these findings were not replicated prospectively. Further work is required with repeat IGF sampling during follow up to see if IGF levels play any role in predicting future lung function through the life course.
机译：胰岛素样生长因子是肽激素，在人体组织（包括呼吸道）的发育，生长和修复中具有内分泌作用。迄今为止，仅存在一项人口研究，该研究发现与IGF-I和更高的肺活量呈正相关。我们假设较高的IGF-I，IGF-II，IGFBP-3和IGF摩尔比与更好的横断面和纵向肺功能有关。我们在Caerphilly前瞻性研究（CaPS）中从周围获得的血液样本中检查了IGF-I，IGF-II，IGFBP-3和IGF摩尔比与肺功能的横断面（n = 843）和前瞻性关联（n = 717） 1986年，在同一年和2003年左右进行了肺活量测定（一秒用力呼气量（FEV1）和用力肺活量（FVC））。较高的IGF摩尔比与简单的横截面改善FEV1 / FEV比有关（ 0.007，95％CI 0.001-0.013，P = 0.02）和完全调整（0.001，95％CI 0.001-0.012，P = 0.03）模型。除了简单模型中的IGFBP-3和FEV1 / FVC（0.009，95％CI 0.001-0.018，P = 0.04）外，所有IGF与肺活量测定值之间的前瞻性关联均与机会一致。在这项男性研究中，较高的IGF摩尔比与改善的横断面肺功能有关，尽管这些发现未得到前瞻性重复。在随访过程中，需要重复进行IGF采样以进一步了解IGF水平在整个生命过程中对未来肺功能的预测中是否起作用。

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