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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Practical detection of a definitive biomarker panel for Alzheimera??s disease; comparisons between matched plasma and cerebrospinal fluid
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Practical detection of a definitive biomarker panel for Alzheimera??s disease; comparisons between matched plasma and cerebrospinal fluid

机译：实际检测确定的阿尔茨海默氏病生物标志物;血浆和脑脊液之间的比较

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Previous mass spectrometry analysis of cerebrospinal fluid (CSF) has allowed the identification of a panel of molecular markers that are associated with Alzheimer’s disease (AD). The panel comprises Amyloid beta, Apolipoprotein E, Fibrinogen alpha chain precursor, Keratin type I cytoskeletal 9, Serum albumin precursor, SPARC-like 1 protein and Tetranectin. Here we report the development and implementation of immunoassays to measure the abundance and diagnostic capacity of these putative biomarkers in matched lumbar CSF and blood plasma samples taken in life from individuals confirmed at post-mortem as suffering from AD (n = 10) and from screened ‘cognitively healthy’ subjects (n = 18). The inflammatory components of Alzheimer’s disease were also investigated. Employment of supervised learning techniques permitted examination of the interrelated expression patterns of the putative biomarkers and identified inflammatory components, resulting in biomarker panels with a diagnostic accuracy of 87.5% and 86.7% for the plasma and CSF datasets respectively. This is extremely important as it offers an ideal high-throughput and relatively inexpensive population screening approach. It appears possible to determine the presence or absence of AD based on our biomarker panel and it seems likely that a cheap and rapid blood test for AD is feasible.
机译：先前对脑脊液（CSF）进行的质谱分析可以鉴定与阿尔茨海默氏病（AD）相关的一系列分子标记。该组包括淀粉样蛋白β，载脂蛋白E，纤维蛋白原α链前体，角蛋白I型细胞骨架9，血清白蛋白前体，SPARC样1蛋白和四联蛋白。在这里，我们报告免疫测定的发展和实施情况，以测量死后确诊患有AD（n = 10）并经筛查的个体的匹配腰CSF和血浆样本中这些推定生物标志物的丰度和诊断能力“认知健康”受试者（n = 18）。还研究了阿尔茨海默氏病的炎症成分。使用监督学习技术可以检查假定的生物标志物的相关表达模式并鉴定出炎症成分，从而使生物标志物组对血浆和CSF数据集的诊断准确性分别为87.5％和86.7％。这一点非常重要，因为它提供了理想的高通量且相对便宜的人群筛选方法。似乎有可能根据我们的生物标记物来确定是否存在AD，并且廉价，快速的AD血液检查似乎可行。

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