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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Evaluations of life style factors and the severity of Gastroesophageal reflux disease; a case-control study
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Evaluations of life style factors and the severity of Gastroesophageal reflux disease; a case-control study

机译：评估生活方式因素和胃食管反流病的严重程度;病例对照研究

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The incidence of Gastroesophageal reflux disease (GERD) has increased remarkably worldwide. This study focuses on the background features of these patients and evaluates the two GERD sub types; none erosive (NERD) and erosive (ERD). In a case-control study, patients with reflux symptoms who had obtained a total score of 8-18 of the GERD questionnaire were included. Control group consisted of their families with lower scores and no reflux presentations. All demographic features were recorded. Then upper GI endoscopy performed and the cases divided into two sub groups: NERD and ERD. In the next step, all demographic data analyzed for these two subgroups. The data were analyzed using the SPSS software version 21. A number of 210 subjects included in each group (210 patients with GERD and 210 control group) with normal statistical distribution of age and gender. There was a significant relationship between GERD and BMI (P=0.001), eating fatty foods (P=0.0001), lying after meal (P=0.0001), drinking beverages with meal (0.0001), eating spicy food (0.006) and NSAIDs use (P=0.0001). Then the cases divided into two subgroups; NERD (n=146) and ERD (n=64). There were a significant relationship with eating salty-smoky food (P=0.005) and eating spicy food (P=0.011). The difference of BMI between NERD and ERD was remarkable but was not statistically significant. Our results showed that obesity is an important risk factor for GERD. Other possible risk factors such as NSAIDs use and certain foods and wrong habits like lying after meal should be addressed in future longitudinal surveys.
机译：在全球范围内，胃食管反流病（GERD）的发病率显着增加。这项研究关注这些患者的背景特征，并评估了两种GERD亚型。无侵蚀性（NERD）和侵蚀性（ERD）。在一项病例对照研究中，纳入了反流症状患者，他们获得了GERD问卷总分8-18分。对照组由得分较低且无反流表现的家庭组成。记录所有人口统计特征。然后进行上消化道内窥镜检查，并将病例分为NERD和ERD两个子组。下一步，将分析这两个子组的所有人口统计数据。使用SPSS软件21版对数据进行分析。每组中包括210名受试者（210名患有GERD的患者和210名对照组），这些受试者的年龄和性别具有正态统计分布。 GERD和BMI（P = 0.001），吃高脂食物（P = 0.0001），饭后躺着（P = 0.0001），饭后喝饮料（0.0001），进食辛辣食物（0.006）和使用NSAID之间存在显着相关性（P = 0.0001）。然后将案例分为两个子组。 NERD（n = 146）和ERD（n = 64）。进食咸烟熏食物（P = 0.005）和进食辛辣食物（P = 0.011）之间存在显着关系。 NERD和ERD之间的BMI差异显着，但无统计学意义。我们的结果表明，肥胖是GERD的重要危险因素。其他可能的危险因素，例如使用非甾体抗炎药和某些食物以及错误的习惯（如饭后躺卧），应在以后的纵向调查中予以解决。

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