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首页> 外文期刊>International journal of molecular imaging >123I-MIBG Scintigraphy as a Powerful Tool to Plan an Implantable Cardioverter Defibrillator and to Assess Cardiac Resynchronization Therapy in Heart Failure Patients
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123I-MIBG Scintigraphy as a Powerful Tool to Plan an Implantable Cardioverter Defibrillator and to Assess Cardiac Resynchronization Therapy in Heart Failure Patients

机译：123I-MIBG闪烁照相术是计划植入式心脏复律除颤器和评估心力衰竭患者心脏再同步治疗的有力工具

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摘要

Iodine-123-metaiodobenzylguanidine (123I-MIBG) scintigraphy is a nuclear medicine technique which describes the functional status of the cardiac sympathetic nervous system. It is well known that an autonomic dysfunction is present in heart failure setting as a neuronal uptake of norepinephrine is impaired in the failing myocardium. Reduction in sympathetic nervous function in the heart, measured by reduced myocardial uptake of123I-MIBG, is an indicator of poor prognosis for heart failure patients. The aim of this paper was to investigate the role of123I-MIBG scintigraphy in evaluating the need of implantable cardioverter defibrillator (ICD) and the response to cardiac resynchronization therapy (CRT) in heart failure patients. For this purpose scientific literature data on these topics were reviewed. Based on literature data,123I-MIBG scintigraphy seems to be a useful tool to assess which patients may benefit most from an ICD implantation to reduce the risk of ventricular arrhythmia or sudden cardiac death. Furthermore,123I-MIBG scintigraphy seems to predict which patients will response to CRT with an improvement in left ventricular function.
机译：碘123-蛋氨酸苄基胍（123I-MIBG）闪烁显像是一种核医学技术，它描述了心脏交感神经系统的功能状态。众所周知，在心力衰竭中存在自主神经功能障碍，因为在衰竭的心肌中，去甲肾上腺素的神经元摄取受到损害。通过减少对123I-MIBG的心肌摄取，可以测量心脏交感神经功能的降低，这是心力衰竭患者预后不良的指标。本文旨在探讨123I-MIBG闪烁显像在评估心力衰竭患者中是否需要植入式心脏复律除颤器（ICD）和对心脏再同步治疗（CRT）的反应中的作用。为此，对有关这些主题的科学文献数据进行了审查。根据文献数据，123I-MIBG闪烁显像似乎是评估哪些患者可能最受益于ICD植入以减少室性心律不齐或心源性猝死风险的有用工具。此外，123I-MIBG闪烁显像似乎可以预测哪些患者会对CRT做出反应并改善左心室功能。

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