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首页> 外文期刊>International journal of molecular imaging >Effects of ROI Placement on PET-Based Assessment of Tumor Response to Therapy
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Effects of ROI Placement on PET-Based Assessment of Tumor Response to Therapy

机译：ROI放置对基于PET的肿瘤治疗反应评估的影响

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Purpose. Quantitative PET response assessment during therapy requires regions of interest (ROI). Commonly, a fixed-size ROI is placed at the maximum uptake point in the pretreatment study. For intratreatment, the ROI is placed either at the maximum uptake point (ROIpeak) or at the same location as the pretreatment ROI (ROIsame). We have evaluated the effects of the ROI placement on response assessment.Methods. PET scans of 15 head and neck cancer patients were used to evaluate the effects of the two ROI methods on response assessment.Results. The average intratreatment ROIpeakuptake was 13.4% higher than the ROIsameuptake (range −14% to 38%). The average relative change in ROIpeakuptake was 7.9% lower than ROIsameuptake (range −5% to 36%), resulting in ambiguous tumour classification in 19% of the tumours.Conclusion. Quantitative PET response assessment using a fixed-size ROI is sensitive the ROI placement. The difference between ROIpeakand ROIsamecould be substantial resulting in ambiguous response assessment. Although the fixed-size ROI is simple to implement, it is also prone to the limitations and should be used with caution. Clinical trial data are necessary to establish reliable thresholds for fixed-size ROI techniques and to evaluate their efficacy for response assessment.
机译：目的。治疗期间的定量PET反应评估需要关注区域（ROI）。通常，在预处理研究中将固定大小的ROI置于最大吸收点。对于治疗内，将ROI放置在最大吸收点（ROIpeak）或与治疗前ROI（ROIsame）相同的位置。我们已经评估了ROI放置对响应评估的影响。使用15位头颈癌患者的PET扫描来评估两种ROI方法对反应评估的效果。治疗中的平均ROI峰值摄入量比ROI相同摄入量高13.4％（范围-14％至38％）。 ROI峰值摄取的平均相对变化比ROI峰值摄取低7.9％（范围-5％至36％），导致19％的肿瘤肿瘤分类不明确。使用固定大小的ROI进行定量PET反应评估对ROI位置很敏感。 ROIpeak和ROIs之间的差异可能相当大，从而导致响应评估不明确。尽管固定大小的ROI易于实现，但它也容易受到限制，应谨慎使用。临床试验数据对于建立固定大小的ROI技术的可靠阈值并评估其疗效评估的必要条件。

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