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首页> 外文期刊>International journal of molecular imaging >Quantitative Accuracy of Low-Count SPECT Imaging in Phantom andIn VivoMouse Studies
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Quantitative Accuracy of Low-Count SPECT Imaging in Phantom andIn VivoMouse Studies

机译：幻影和体内小鼠研究中低计数SPECT成像的定量精度

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We investigated the accuracy of a single photon emission computed tomography (SPECT) system in quantifying a wide range of radioactivity concentrations using different scan times in both phantom and animal models. A phantom containing various amounts of In-111 or Tc-99m was imaged until the activity had decayed close to background levels. Scans were acquired for different durations, employing different collimator pinhole sizes. VOI analysis was performed to quantify uptake in the images and the values compared to the true activity. The phantom results were then validated in tumour-bearing mice. The use of an appropriate calibration phantom and disabling of a background subtraction feature meant that absolute errors were within 12% of the true activity. Furthermore, a comparison ofin vivoimaging and biodistribution studies in mice showed a correlation of 0.99 for activities over the 200 kBq to 5 MBq range. We conclude that the quantitative information provided by the NanoSPECT camera is accurate and allows replacement of dissection studies for assessment of radiotracer biodistribution in mouse models.
机译：我们研究了幻影模型和动物模型中使用不同扫描时间的宽范围放射性浓度定量的单光子发射计算机断层扫描（SPECT）系统的准确性。对包含各种含量的In-111或Tc-99m的体模进行成像，直到活性衰减到接近背景水平为止。使用不同的准直仪针孔尺寸，获得了不同持续时间的扫描。进行VOI分析以量化图像中的摄取以及与真实活性相比的值。然后在荷瘤小鼠中验证了幻像结果。使用适当的校准体模并禁用背景扣除功能意味着绝对误差在真实活动的12％以内。此外，对小鼠体内成像和生物分布研究的比较显示，在200 kBq至5 MBq范围内的活性相关性为0.99。我们得出的结论是，NanoSPECT相机提供的定量信息是准确的，并且可以替代解剖研究以评估小鼠模型中放射性示踪剂的生物分布。

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